Hormonal Stimulation of Human Ovarian Xenografts in Mice: Studying Folliculogenesis, Activation, and Oocyte Maturation
| Autor: | Ariella Shikanov, Monica A. Wall, Vasantha Padmanabhan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Reproductive Techniques Assisted Xenotransplantation medicine.medical_treatment Biology Bioinformatics 03 medical and health sciences Mice 0302 clinical medicine Endocrinology Oogenesis Ovarian Follicle Internal medicine medicine Animals Humans Ovarian tissue cryopreservation Fertility preservation Ovarian reserve Oncofertility 030219 obstetrics & reproductive medicine Assisted reproductive technology Mini-Reviews Ovary Fertility Preservation Transplantation 030104 developmental biology Heterografts Female Folliculogenesis |
| Zdroj: | Endocrinology |
| ISSN: | 1945-7170 |
| Popis: | Ovarian tissue cryopreservation and banking provides a fertility preservation option for patients who cannot undergo oocyte retrieval; it is quickly becoming a critical component of assisted reproductive technology programs across the world. While the transplantation of cryopreserved ovarian tissue has resulted in over 130 live births, the field has ample room for technological improvements. Specifically, the functional timeline of grafted tissue and each patient’s probability of achieving pregnancy is largely unpredictable due to patient-to-patient variability in ovarian reserve, lack of a reliable method for quantifying follicle numbers within tissue fragments, potential risk of reintroduction of cancer cells harbored in ovarian tissues, and an inability to control follicle activation rates. This review focuses on one of the most common physiological techniques used to study human ovarian tissue transplantation, xenotransplantation of human ovarian tissue to mice and endeavors to inform future studies by discussing the elements of the xenotransplantation model, challenges unique to the use of human ovarian tissue, and novel tissue engineering techniques currently under investigation. |
| Databáze: | OpenAIRE |
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