Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity
| Autor: | Ramón Cañete, Miguel Valle, Rosario Valle-Martos, Rosario Martos, María Dolores Cañete, Luis Jiménez-Reina |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
obesity prepuberal age Adipokine 030209 endocrinology & metabolism Pediatrics metabolic syndrome 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Medicine Endothelial dysfunction Original Research Adiponectin business.industry Leptin Fatty liver lcsh:RJ1-570 lcsh:Pediatrics medicine.disease Obesity endothel dysfunction liver enzymes Endocrinology inflammation Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology Metabolic syndrome business |
| Zdroj: | Frontiers in Pediatrics Frontiers in Pediatrics, Vol 9 (2021) |
| ISSN: | 2296-2360 |
| Popis: | Background: Metabolic syndrome (MetS) can start in children with obesity at very young ages. Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic component of metabolic syndrome. If left untreated, the clinical course of NAFLD can be progressive and can become chronic if not detected at an early stage.Objective: We aimed to quantify the differences in liver enzymes between prepubertal children with obesity and children with normal weight to determine any associations between them and parameters related to MetS, adipokines, or markers of endothelial dysfunction and inflammation.Methods: This cross-sectional study included 54 prepuberal children with obesity (aged 6–9 years) and 54 children with normal weight, matched by age and sex. Liver enzymes, C-reactive protein (CRP), interleukin-6, soluble intercellular adhesion molecule-1 (sICAM-1), adipokines, and parameters related to metabolic syndrome (MetS) were all measured.Results: Alanine aminotransferase (ALT) levels, serum butyryl cholinesterase (BChE), leptin, CRP, sICAM-1, triglycerides, blood pressure, and homeostasis model assessment for insulin resistance were significantly higher in children with obesity, while Apolipoprotein A-1, HDL-cholesterol, and adiponectin were significantly lower. In the children with obesity group, ALT and BChE levels correlated with anthropometric measurements, insulin resistance, and lipid parameters, leptin, interleukin-6, CRP, and sICAM-1 while BChE levels negatively correlated with adiponectin.Conclusions: Compared to children with normal weight, prepubertal children with obesity had elevated values for liver enzymes, leptin, markers of insulin resistance, inflammation, and endothelial dysfunction, and variables associated with MetS. There was also a correlation between these disorders and liver enzyme levels. |
| Databáze: | OpenAIRE |
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