Racial and Ethnic Variation in Lipoprotein (a) Levels among Asian Indian and Chinese Patients
| Autor: | Dipanjan Banerjee, Latha Palaniappan, Stephen P. Fortmann, Jessica J. Shin, Eric C. Wong |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Article Subject
Ethnic group 030204 cardiovascular system & hematology Logistic regression Biochemistry lcsh:Physiology lcsh:Biochemistry 03 medical and health sciences 0302 clinical medicine Medicine lcsh:QD415-436 030212 general & internal medicine Risk factor Chinese americans lcsh:QP1-981 Traditional medicine biology business.industry Asian Indian Chinese adults Lipoprotein(a) 3. Good health biology.protein business Niacin Demography Research Article |
| Zdroj: | Journal of Lipids Journal of Lipids, Vol 2011 (2011) |
| ISSN: | 2090-3030 |
| DOI: | 10.1155/2011/291954 |
| Popis: | Background. Lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease (CVD) in Non-Hispanic Whites (NHW). There are known racial/ethnic differences in Lp(a) levels, and the association of Lp(a) with CVD outcomes has not been examined in Asian Americans in the USA.Objective. We hypothesized that Lp(a) levels would differ in Asian Indians and Chinese Americans when compared to NHW and that the relationship between Lp(a) and CVD outcomes would be different in these Asian racial/ethnic subgroups when compared to NHW.Methods. We studied the outpatient electronic health records of 2022 NHW, 295 Asian Indians, and 151 Chinese adults age≥18 y in Northern California in whom Lp(a) levels were assessed during routine clinical care from 2001 to 2008, excluding those who had received prescriptions for niacin (14.6%). Nonparametric methods were used to compare median Lp(a) levels. Significance was assessed at theP<.0001level to account for multiple comparisons. CVD outcomes were defined as ischemic heart disease (IHD) (265 events), stroke (122), or peripheral vascular disease (PVD) (87). We used logistic regression to determine the relationship between Lp(a) and CVD outcomes.Results. Both Asian Indians (36 nmol/L) and NHW (29 nmol/L) had higher median Lp(a) levels than Chinese (22 nmol/L,P≤.0001andP=.0032). When stratified by sex, the differences in median Lp(a) between these groups persisted in the 1761 men (AI v CH:P=.001, NHW v CH:P=.0018) but were not statistically significant in the 1130 women (AI v CH:P=.0402, NHW v CH:P=.0761). Asian Indians (OR=2.0) and Chinese (OR=4.8) exhibited a trend towards greater risk of IHD with high Lp(a) levels than NHW (OR=1.4), but no relationship was statistically significant.Conclusion. Asian Indian and NHW men have higher Lp(a) values than Chinese men, with a trend toward, similar associations in women. High Lp(a) may be more strongly associated with IHD in Asian Indians and Chinese, although we did not have a sufficient number of outcomes to confirm this. Further studies should strive to elucidate the relationship between Lp(a) levels, CVD, and race/ethnicity among Asian subgroups in the USA. |
| Databáze: | OpenAIRE |
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