SARS-CoV-2 in Urine May Predict a Severe Evolution of COVID-19
| Autor: | Valentina Orlando, Simona Cotena, Francesco Coletta, Marina Tarsitano, Marco Perrella, Romolo Villani, Crescenzo Sala, Matteo Della Monica, Massimo Chetta, Antonio Tomasello, Dania Sannino, Mario Brita, Giuseppe Lo Russo, Enrico Coscioni, GiamPaola De Marco, Alessandro Perrella, Adele Longobardi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Urine Fibrinogen Gastroenterology Article Internal medicine Intensive care medicine atypical COVID-19 SARS-CoV-2 business.industry Mortality rate unusual COVID COVID-19 SARS-CoV-2 urine General Medicine medicine.anatomical_structure Breathing Medicine Sputum medicine.symptom business medicine.drug Respiratory tract |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 4061, p 4061 (2021) Volume 10 Issue 18 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10184061 |
| Popis: | We hypothesized that the spread of SARS-CoV-2 in urine during a severe COVID-19 infection may be the expression of the worsening disease evolution. Therefore, the aim of this study was to verify if the COVID-19 disease severity is related to the viral presence in urine samples. We evaluated the clinical evolution in acute COVID-19 patients admitted in the sub-intensive care and intensive care units between 28 of December 2020 and 15th of February 2021 and being positive for SARS-CoV-2 RNA in the respiratory tract, including repeated endotracheal aspirates (ETA), sputum, nasopharyngeal swabs (NPS) and urine. We found that those subjects with SARS-COV-2 in the urine at admittance (8 out of 60 eligible patients) had a more severe disease than those with negative SARS-CoV-2 in urine. Further, they showed an increase in fibrinogen and (C-reactive Protein) CRP serum levels, requiring mechanic ventilation. Of those with positive SARS-CoV-2 in the urine, 50% died. According to our preliminary results, it seems that the presence of SARS-CoV-2 in the urine characterizes patients with a more severe disease and is also related to a higher death rate. |
| Databáze: | OpenAIRE |
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