Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology
| Autor: | U. di Porzio, Carlo Cavaliere, Michele Papa, Eva M. Marco, Emilia Romano, Walter Adriani, Giovanni Laviola, Giovanni Cirillo, Carla Perrone-Capano, Damiana Leo |
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| Přispěvatelé: | Leo, D, Adriani, W, Cavaliere, C, Cirillo, G, Marco, Em, Romano, E, DI PORZIO, U, Papa, Michele, PERRONE CAPANO, C, Laviola, G. |
| Rok vydání: | 2009 |
| Předmět: |
Agonist
Male Aging Serotonin Neurite medicine.drug_class Presynaptic Terminals Nucleus accumbens Cell Enlargement Impulsivity Nucleus Accumbens Behavioral Neuroscience Reward Neuroplasticity Genetics medicine Neurites Animals Rats Wistar Cells Cultured Neurons Neuronal Plasticity Behavior Animal Methylphenidate Antagonist Rats Serotonin Receptor Agonists Disease Models Animal Neurology Receptors Serotonin Impulsive Behavior Brain stimulation reward Central Nervous System Stimulants Female Serotonin Antagonists medicine.symptom Psychology Neuroscience medicine.drug |
| Zdroj: | 8 (2009): 356–368. info:cnr-pdr/source/autori:Leo D, Adriani W, Cavaliere C, Cirillo G, Marco EM, Romano E, di Porzio U, Papa M, Perrone-Capano C, Laviola G/titolo:Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology/doi:/rivista:/anno:2009/pagina_da:356/pagina_a:368/intervallo_pagine:356–368/volume:8 |
| ISSN: | 1601-183X |
| Popis: | Methylphenidate (MPH) administration to adolescent rodents produces persistent region-specific changes in brain reward circuits and alterations of reward-based behavior. We show that these modifications include a marked increment of serotonin (5-hydroxy-tryptamine) receptor type 7 (Htr7) expression and synaptic contacts, mainly in the nucleus accumbens, and a reduction of basal behavioral impulsivity. We show that neural and behavioral consequences are functionally related: administration of a selective Htr7 antagonist fully counteracts the MPH-reduced impulsive behavior and enhances impulsivity when administered alone in naive rats. Agonist-induced activation of endogenous Htr7 significantly increases neurite length in striatal neuron primary cultures, thus suggesting plastic remodeling of neuronal morphology. The mixed Htr (1a/7) agonist, 8-OH-DPAT, reduces impulsive behavior in adolescent rats and in naive adults, whose impulsivity is enhanced by the Htr7 antagonist. In summary, behavioral pharmacology experiments show that Htr7 mediates self-control behavior, and brain primary cultures experiments indicate that this receptor may be involved in the underlying neural plasticity, through changes in neuronal cytoarchitecture. |
| Databáze: | OpenAIRE |
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