Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatmen
| Autor: | Ssang-Goo Cho, Ahmed Abdal Dayem, Kyung Min Lim, Iyer Mahalaxmi, Neethu Raj, Se Jong Kim, Jong Yub An, Yujin Choi, Mohana Devi Subramaniam, Yoonjoo Lee, Kaavya Jayaramayya, Balachandar Vellingiri, Arthi Kirubhakaran |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Coronavirus disease 2019 (COVID-19)
Pneumonia Viral Mesenchymal stem cells (MSCs) Exosomes Mesenchymal Stem Cell Transplantation Biochemistry Exosome Immunomodulation Betacoronavirus Immune system Ongoing Clinical trials Medicine Humans Molecular Biology Pandemics business.industry SARS-CoV-2 Mesenchymal stem cell Treatment options COVID-19 Mesenchymal Stem Cells General Medicine medicine.disease Microvesicles Invited Mini Review Immune System Immunology Cytokines Therapy Stem cell business Cytokine storm Coronavirus Infections |
| Zdroj: | BMB Reports |
| ISSN: | 1976-670X 1976-6696 |
| Popis: | The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Since the immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The use of stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) as therapeutic opportunities for various diseases. The MSCs and MSCExos have immunomodulatory functions; they can be used as therapy to strike a balance in the immune cells of patients with COVID-19. In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19. [BMB Reports 2020; 53(8): 400-412]. |
| Databáze: | OpenAIRE |
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