Kinetics and efficacy of deferoxamine in iron-overloaded hemodialysis patients
| Autor: | J. C. Stivelman, Lazarus Jm, Raymond M. Hakim, M Fosburg, G Schulman |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Iron Kinetics Urology Deferoxamine Iron Chelating Agents Ferric Compounds Excretion Pharmacokinetics Renal Dialysis Medicine Humans Dialysis Chemotherapy Feroxamine business.industry Middle Aged Surgery Nephrology Female Hemodialysis business medicine.drug |
| Zdroj: | Kidney international. 36(6) |
| ISSN: | 0085-2538 |
| Popis: | Kinetics and efficacy of deferoxamine in iron-overloaded hemodialysis patients. We evaluated the kinetics and efficacy of deferoxamine (DFO) therapy in iron-overloaded hemodialysis patients. Concentrations of DFO and its chelated product, feroxamine (Fx), were assessed following single-dose DFO administration in twelve patients, and during chronic therapy over one year's time in eight, similarly iron-overloaded dialysis patients. A functional assay which relies on measurements of iron and iron binding capacity for the determination of Fx and DFO, respectively, was corroborated with liquid chromatographic techniques. Half-life measurements were also corroborated with tracer doses of 14C-DFO and 59Fe-feroxamine. Intradialytic DFO half-life (2.3 ± 1.1 h) was considerably less than interdialytic half-life (26 ± 1 hr). Unbound DFO was found to persist throughout the interdialytic period. Calculation of the percent saturation of the DFO dose indicated that only 30% of a given dose is chelated. The amount of iron removed dialytically was approximately 13.1 ±2.7mg per dialysis session. Chronic DFO administration was also shown to enhance gastrointestinal iron excretion threefold. However, ferritin levels decreased by only 25% after one year of thrice-weekly DFO therapy. We conclude that DFO therapy for iron-overloaded hemodialysis patients is optimized by its administration interdialytically, and results in slow removal of iron, via both dialytic and gastrointestinal routes. |
| Databáze: | OpenAIRE |
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