Brain reward-system activation in response to anticipation and consumption of palatable food is altered by glucagon-like peptide-1 receptor activation in humans

Autor: L. van Bloemendaal, John H. Sloan, Henricus G. Ruhé, Frederik Barkhof, Michaela Diamant, Dick J. Veltman, J. S. ten Kulve, Paul F. C. Groot, Richard G. IJzerman
Přispěvatelé: Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Internal medicine, Anatomy and neurosciences, Psychiatry, Radiology and nuclear medicine, NCA - Neurobiology of mental health, ICaR - Circulation and metabolism, Other departments, Radiology and Nuclear Medicine
Rok vydání: 2015
Předmět:
Male
obesity
EXENATIDE
Endocrinology
Diabetes and Metabolism
Appetite
Endocrinology
Weight loss
Overeating
media_common
digestive
oral
and skin physiology
Brain
Middle Aged
OPEN-LABEL
Magnetic Resonance Imaging
food reward
Anticipation
ORBITOFRONTAL CORTEX
Milk
functional MRI
Female
type 2 diabetes
medicine.symptom
BEHAVIOR
medicine.drug
Adult
Agonist
endocrine system
medicine.medical_specialty
medicine.drug_class
media_common.quotation_subject
WEIGHT-LOSS
Glucagon-Like Peptide-1 Receptor
food
Reward
Internal medicine
Internal Medicine
medicine
Animals
Humans
Hypoglycemic Agents
EXENDIN-4
Aged
Cacao
Motivation
Venoms
business.industry
Feeding Behavior
Anticipation
Psychological
Peptide Fragments
RANDOMIZED-TRIAL
food.food
ENERGY-INTAKE
Diabetes Mellitus
Type 2
glucagon-like peptide-1
Chocolate milk
Orbitofrontal cortex
Peptides
GLP-1
business
Exenatide
Zdroj: Diabetes obesity & metabolism, 17(9), 878-886. Wiley
Diabetes, Obesity and Metabolism, 17(9), 878-886. Wiley-Blackwell
Diabetes, obesity & metabolism, 17(9), 878-886. Wiley-Blackwell
van Bloemendaal, L, Veltman, D J, ten Kulve, J S, Groot, P F C, Ruhe, H G, Barkhof, F, Sloan, J H, Diamant, M & IJzerman, R G 2015, ' Brain reward-system activation in response to anticipation and consumption of palatable food is altered by glucagon-like peptide-1 receptor activation in humans ', Diabetes, Obesity and Metabolism, vol. 17, no. 9, pp. 878-886 . https://doi.org/10.1111/dom.12506
ISSN: 1462-8902
Popis: AimTo test the hypothesis that food intake reduction after glucagon-like peptide-1 (GLP-1) receptor activation is mediated through brain areas regulating anticipatory and consummatory food reward.MethodsAs part of a larger study, we determined the effects of GLP-1 receptor activation on brain responses to anticipation and receipt of chocolate milk versus a tasteless solution, using functional MRI (fMRI). Obese subjects with type 2 diabetes, and obese and lean subjects with normoglycaemia (n=48) underwent three fMRI sessions at separate visits with intravenous infusion of the GLP-1 receptor agonist exenatide, exenatide with prior GLP-1 receptor blockade by exendin-9-39 or placebo, during somatostatin pituitary-pancreatic clamps.ResultsBody mass index negatively correlated with brain responses to receipt of chocolate milk and positively correlated with anticipation of receipt of chocolate milk in brain areas regulating reward, appetite and motivation. Exenatide increased brain responses to receipt of chocolate milk and decreased anticipation of receipt of chocolate milk compared with placebo, paralleled by reductions in food intake. Exendin-9-39 largely prevented these effects.ConclusionsOur findings show that GLP-1 receptor activation decreases anticipatory food reward, which may reduce cravings for food and increases consummatory food reward, which may prevent overeating.
Databáze: OpenAIRE
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