Multivalent grafting of hyperbranched oligo- and polyglycerols shielding rough membranes to mediate hemocompatibility
| Autor: | Axel T. Neffe, Tobias Becherer, Karola Lützow, S. Braune, Friedrich Jung, Andreas Lendlein, Klaus Richau, Toralf Roch, Maik von Ruesten-Lange, Anne Krüger, Rainer Haag, Andreas F. Thünemann |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Materials science Dispersity Biomedical Engineering General Chemistry General Medicine Polymer Adhesion Grafting chemistry.chemical_compound Membrane chemistry Chemical engineering Thrombocyte activation ddc:540 Polymer chemistry Institut für Chemie General Materials Science ddc:610 Imide Protein adsorption |
| Zdroj: | Neffe, A.T.; Ruesten-Lange, M.v.; Braune, S.; Luetzow, K.; Roch, T.; Richau, K.; Krueger, A.; Becherer, T.; Thuenemann, A.F.; Jung, F.; Haag, R.; Lendlein, A.: Multivalent grafting of hyperbranched oligo-and polyglycerols shielding rough membranes to mediate hemocompatibility. In: Journal of Materials Chemistry B. Vol. 2 (2014) 23, 3626-3635. (DOI: 10.1039/C4TB00184B) |
| ISSN: | 2050-7518 2050-750X |
| Popis: | Hemocompatible materials are needed for internal and extracorporeal biomedical applications, which should be realizable by reducing protein and thrombocyte adhesion to such materials. Polyethers have been demonstrated to be highly efficient in this respect on smooth surfaces. Here, we investigate the grafting of oligo- and polyglycerols to rough poly(ether imide) membranes as a polymer relevant to biomedical applications and show the reduction of protein and thrombocyte adhesion as well as thrombocyte activation. It could be demonstrated that, by performing surface grafting with oligo- and polyglycerols of relatively high polydispersity (>1.5) and several reactive groups for surface anchoring, full surface shielding can be reached, which leads to reduced protein adsorption of albumin and fibrinogen. In addition, adherent thrombocytes were not activated. This could be clearly shown by immunostaining adherent proteins and analyzing the thrombocyte covered area. The presented work provides an important strategy for the development of application relevant hemocompatible 3D structured materials. |
| Databáze: | OpenAIRE |
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