Chromosome Abnormalities in Skin Fibroblasts Probably Induced by an Anti-cancer Drug
| Autor: | Naoki Sadamori, Takeo Honda, Fumi Toriyama |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Drug Pathology medicine.medical_specialty media_common.quotation_subject Abnormal cell Dermatology Biology Bleomycin chemistry.chemical_compound Peplomycin medicine Humans Penile Neoplasms Cells Cultured Skin media_common Chromosome Aberrations integumentary system Chromosome Cancer General Medicine Fibroblasts Middle Aged medicine.disease medicine.anatomical_structure chemistry Anti cancer drugs Carcinoma Squamous Cell Pepleomycin Penis |
| Zdroj: | The Journal of Dermatology. 17:155-158 |
| ISSN: | 0385-2407 |
| DOI: | 10.1111/j.1346-8138.1990.tb01617.x |
| Popis: | Chromosome findings in cultured skin fibroblasts from a patient treated with an anti-cancer drug, pepleomycin sulfate, for his penis cancer are reported. In two batches of specimens (days 16 and 34, respectively), out of 120 cells examined, a total of 26 abnormal cells (21.7%) were found with no common chromosome abnormalities; there were no clones. This cytogenetic pattern of abnormalities without clones in cultured skin fibroblasts differs from that seen in congenital disease or radiation-exposed skin fibroblasts. It is suggested that the anti-cancer agent is the most likely etiological factor for these uncloned chromosome abnormalities in cultured skin fibroblasts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text