Circulating 25-Hydroxyvitamin D and the Risk of Rarer Cancers: Design and Methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Autor: Christian C. Abnet, Chinonye Harvey, D. Michal Freedman, Demetrius Albanes, Patricia Hartge, Karen L. Koenig, Yong-Bing Xiang, Kimberly A. Bertrand, Ronald L. Horst, Dominick Parisi, Laurence N. Kolonel, Shelley S. Tworoger, Marjorie L. McCullough, Mark P. Purdue, Kathy J. Helzlsouer, Lisa Gallicchio, Wei Zheng, Anne Zeleniuch-Jacquotte, Stephanie J. Weinstein, Jarmo Virtamo, Susan E. Hankinson, Francine Laden, Kirk Snyder, Wong Ho Chow, Arti Varanasi, Virginia Hartmuller, Rachael Z. Stolzenberg-Solomon, Lynne R. Wilkens, Kai Yu, Richard B. Hayes, Xiao-Ou Shu
Rok vydání: 2010
Předmět:
Adult
Male
Oncology
China
medicine.medical_specialty
Esophageal Neoplasms
Epidemiology
Original Contributions
neoplasms
vitamin D
vitamin D deficiency
methods
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Meta-Analysis as Topic
Risk Factors
Stomach Neoplasms
Internal medicine
Vitamin D and neurology
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Risk factor
Prospective cohort study
Finland
Ovarian Neoplasms
business.industry
Lymphoma
Non-Hodgkin
case-control studies
Case-control study
Vitamin D Deficiency
medicine.disease
Kidney Neoplasms
United States
Endometrial Neoplasms
3. Good health
Non-Hodgkin's lymphoma
Pancreatic Neoplasms
Logistic Models
Endocrinology
Research Design
030220 oncology & carcinogenesis
Cohort
Female
business
Cohort study
Zdroj: American Journal of Epidemiology
ISSN: 1476-6256
0002-9262
DOI: 10.1093/aje/kwq116
Popis: The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP), a consortium of 10 prospective cohort studies from the United States, Finland, and China, was formed to examine the associations between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of rarer cancers. Cases (total n = 5,491) included incident primary endometrial (n = 830), kidney (n = 775), ovarian (n = 516), pancreatic (n = 952), and upper gastrointestinal tract (n = 1,065) cancers and non-Hodgkin lymphoma (n = 1,353) diagnosed in the participating cohorts. At least 1 control was matched to each case on age, date of blood collection (1974–2006), sex, and race/ethnicity (n = 6,714). Covariate data were obtained from each cohort in a standardized manner. The majority of the serum or plasma samples were assayed in a central laboratory using a direct, competitive chemiluminescence immunoassay on the DiaSorin LIAISON platform (DiaSorin, Inc., Stillwater, Minnesota). Masked quality control samples included serum standards from the US National Institute of Standards and Technology. Conditional logistic regression analyses were conducted using clinically defined cutpoints, with 50–
Databáze: OpenAIRE
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