Hepatitis C virus infection in patients with HIV-1: epidemiology, natural history and management
| Autor: | Yongtao Sun, Wen Kang, Hsin-I Tong, Yuanan Lu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cirrhosis
medicine.medical_treatment Hepatitis C virus Population HIV Infections Comorbidity Hepacivirus Liver transplantation medicine.disease_cause Polyethylene Glycols End Stage Liver Disease chemistry.chemical_compound Pharmacotherapy Pegylated interferon Ribavirin Humans Medicine education education.field_of_study Hepatology business.industry Gastroenterology Disease Management Interferon-alpha virus diseases medicine.disease Hepatitis C Recombinant Proteins digestive system diseases Liver Transplantation Treatment Outcome Anti-Retroviral Agents chemistry Hepatocellular carcinoma Immunology Disease Progression HIV-1 business medicine.drug |
| Zdroj: | Expert Review of Gastroenterology & Hepatology. 8:247-266 |
| ISSN: | 1747-4132 1747-4124 |
| DOI: | 10.1586/17474124.2014.876357 |
| Popis: | Hepatitis C virus (HCV)-related liver diseases have contributed to increased morbidity and mortality in HIV-1-infected individuals in the era of effective antiretroviral therapy. HCV transmission patterns have changed among the HIV co-infected population during the last decade, with acute HCV infection emerging worldwide. HIV infection accelerates the progression of HCV-related liver diseases and consequently cirrhosis, liver failure, and hepatocellular carcinoma. However, the current standard treatment of HCV infection with pegylated interferon plus ribavirin results in only a limited viral response. Furthermore, cumbersome pill regimens, antiretroviral related hepatotoxicity, and drug interactions of HCV and HIV regimens complicate therapy strategies. Fortunately, in the near future, new direct-acting anti-HCV agents will widen therapeutic options for HCV/HIV co-infection. Liver transplantation is also gradually accepted as a therapeutic option for end stage liver disease of HCV/HIV co-infected patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|