Antimicrobial Activity of Extracts and Isoquinoline Alkaloids of Selected Papaveraceae Plants
| Autor: | Jakub Smid, Marcela Šafratová, Jakub Chlebek, Lubomír Opletal, Lucie Cahlíková, Miroslav Rozkot, Daniela Hulcová, Adéla Fraňková, Pavel Klouček, Anna Hošt'álková, Miroslav Ločárek |
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| Předmět: |
Plant Science
Microbial Sensitivity Tests medicine.disease_cause Enterococcus faecalis Gas Chromatography-Mass Spectrometry Microbiology Alkaloids Anti-Infective Agents Papaveraceae Drug Discovery medicine heterocyclic compounds Escherichia coli Staphylococcus hyicus Pharmacology Macleaya cordata biology Plant Extracts General Medicine biology.organism_classification Antimicrobial Isoquinolines Proteus mirabilis Complementary and alternative medicine Staphylococcus aureus |
| Zdroj: | ResearcherID Scopus-Elsevier |
| Popis: | Alkaloidal extracts of seven selected plants of the family Papaveraceae were studied with respect to their activity against six strains of pathogenic bacteria and their alkaloidal fingerprint. Twenty-four alkaloids were determined by GC/MS, and twenty of them identified from their mass spectra, retention times and retention indexes. In the antibacterial assay, three Gram-positive ( Enterorococcus faecalis, Staphylococcus aureus and S. hyicus), and three Gram-negative ( Escherichia coli, Proteus mirabilis and Pseudomonas aeruginosa) strains were used. The most promising antimicrobial activity was shown by the alkaloidal extract of Macleaya cordata with MIC values of 16 μg/mL for Staphylococcus aureus, 32 μg/mL for Enterococcus faecalis and 64 μg/mL for Staphylococcus hyicus and Escherichia coli. All the tested pure isoquinoline alkaloids were considered inactive within the tested concentrations. |
| Databáze: | OpenAIRE |
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