CRP gene haplotypes, serum CRP, and cerebral small-vessel disease - The Rotterdam Scan Study and the MEMO study
Autor: | Monique M.B. Breteler, Moniek P.M. de Maat, Monika Stoll, Isabella Kardys, Frauke Friedrichs, Christiane Reitz, Jacqueline C.M. Witteman, Klaus Berger |
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Přispěvatelé: | Hematology, Epidemiology |
Rok vydání: | 2007 |
Předmět: |
Brain Infarction
Genetic Markers Male medicine.medical_specialty Pathology Genotype DNA Mutational Analysis Polymorphism Single Nucleotide Gastroenterology Cohort Studies Pathogenesis Central nervous system disease Risk Factors Polymorphism (computer science) Internal medicine medicine Humans Genetic Predisposition to Disease Genetic Testing Prospective Studies Prospective cohort study Stroke Aged Netherlands Aged 80 and over Advanced and Specialized Nursing Vascular disease business.industry Microcirculation Haplotype Brain Cerebral Arteries Middle Aged Intracranial Arteriosclerosis medicine.disease Magnetic Resonance Imaging Hyperintensity C-Reactive Protein Haplotypes Female Neurology (clinical) Cardiology and Cardiovascular Medicine business |
Zdroj: | Stroke, 38(8), 2356-2359. Lippincott Williams & Wilkins |
ISSN: | 0039-2499 |
Popis: | Background and Purpose— It remains unclear whether C-reactive protein (CRP) is a serum marker for atherothrombotic disease or a causal factor in the pathogenesis of atherosclerosis. We explored the association between CRP gene variations and cerebral small-vessel disease (SVD) in the Rotterdam Scan Study (N=1035) and the MEMO Study (N=268). Methods— Common haplotypes within the CRP gene were determined by genotype-tagging single-nucleotide polymorphisms. Then their relation with periventricular and subcortical white matter lesions and the prevalence of lacunar brain infarcts was explored by regression analyses. Results— There was no association between CRP haplotypes and measures of cerebral SVD in either study. There was no effect modification of the association between serum CRP levels and measures of SVD by CRP haplotypes. Conclusions— Our observations suggest that CRP is not causally involved in the pathogenesis of SVD. |
Databáze: | OpenAIRE |
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