CHRONIC INFLAMMATORY RESPONSES TO MICROGEL-BASED IMPLANT COATINGS
| Autor: | Amanda W. Bridges, Julia E. Babensee, Kellie L. Templeman, Neetu Singh, Rachel E. Whitmire, Andrés J. García, L. Andrew Lyon |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Materials science Polymers Biomedical Engineering Acrylic Resins Inflammation Article Biomaterials chemistry.chemical_compound Coated Materials Biocompatible Implants Experimental Polymer chemistry Materials Testing medicine Polyethylene terephthalate Animals Rats Wistar Acrylic resin Acrylamides Foreign-Body Reaction Metals and Alloys Biomaterial Hydrogels medicine.disease Rats chemistry visual_art Self-healing hydrogels Ceramics and Composites visual_art.visual_art_medium Implant medicine.symptom Ethylene glycol Foreign body granuloma Biomedical engineering |
| Popis: | Inflammatory responses to implanted biomedical devices elicit a foreign body fibrotic reaction that limits device integration and performance in various biomedical applications. We examined chronic inflammatory responses to microgel conformal coatings consisting of thin films of poly(N-isopropylacrylamide) hydrogel microparticles cross-linked with poly(ethylene glycol) diacrylate deposited on poly(ethylene terephthalate) (PET). Unmodified and microgel-coated PET disks were implanted subcutaneously in rats for 4 weeks and explants were analyzed by histology and immunohistochemistry. Microgel coatings reduced chronic inflammation and resulted in a more mature/organized fibrous capsule. Microgel-coated samples exhibited 22% thinner fibrous capsules that contained 40% fewer cells compared to unmodified PET disks. Furthermore, microgel-coated samples contained significantly higher levels of macrophages (80%) than unmodified PET controls. These results demonstrate that microgel coatings reduce chronic inflammation to implanted biomaterials. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010. |
| Databáze: | OpenAIRE |
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