Effect of long-term GH replacement therapy on cardiovascular outcomes in isolated GH deficiency compared with multiple pituitary hormone deficiencies: a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults
| Autor: | Madeleine L. Drent, Christa C. van Bunderen, Martijn W. Heymans, Carline J van den Dries, A.A.M. Franken, H. P. F. Koppeschaar, Aart Jan van der Lely |
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| Přispěvatelé: | Internal medicine, Epidemiology and Data Science, NCA - Neurobiology of mental health, Internal Medicine, Methodology and Applied Biostatistics, Clinical Neuropsychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Hormone Replacement Therapy Endocrinology Diabetes and Metabolism medicine.medical_treatment Arginine Hypopituitarism Body Mass Index Endocrinology SDG 3 - Good Health and Well-being Risk Factors Diabetes mellitus Internal medicine medicine Humans Insulin Insulin-Like Growth Factor I Triglycerides medicine.diagnostic_test business.industry Human Growth Hormone General Medicine Middle Aged medicine.disease Growth hormone treatment Blood pressure Cholesterol Transgender hormone therapy Cardiovascular Diseases IGHD Female Waist Circumference Lipid profile business Body mass index Follow-Up Studies |
| Zdroj: | European Journal of Endocrinology, 171(2), 151-160. BioScientifica Ltd. European Journal of Endocrinology, 171(2), 151-160. Bioscientifica Ltd van Bunderen, C C, van den Dries, C J, Heijmans, M W, Franken, A A M, Koppeschaar, H P F, van der Lely, A J & Drent, M L 2014, ' Effect of long-term GH replacement therapy on cardiovascular outcomes in isolated GH deficiency compared with multiple pituitary hormone deficiencies: a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults ', European Journal of Endocrinology, vol. 171, no. 2, pp. 151-160 . https://doi.org/10.1530/EJE-14-0069 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/EJE-14-0069 |
| Popis: | ObjectiveIsolated GH deficiency (IGHD) could provide a model to investigate the influence of GH deficiency per se and the effect of GH replacement therapy without the influence from other pituitary hormone deficiencies or their treatment. The aim of this study is to address the questions about differences between IGHD and multiple pituitary hormone deficiencies (MPHDs) in clinical presentation and in responsiveness to GH treatment.DesignA nationwide surveillance study was carried out to describe the difference in the clinical presentation and responsiveness to GH treatment of patients with IGHD and MPHDs.MethodsThe Dutch National Registry of GH Treatment in Adults was founded in 1998 to gain more insight into long-term efficacy and safety of GH therapy. Out of 2891 enrolled patients, 266 patients with IGHD at the start of GH treatment were identified and compared with 310 patients with MPHDs. Cardiovascular indices will be investigated at baseline and during long-term follow-up, including body composition, lipid profile, glucose metabolism, blood pressure, and morbidity.ResultsPatients with IGHD and MPHDs were demonstrated to be different entities at clinical presentation. Metabolically, patients with MPHDs had a larger waist circumference, lower HDL cholesterol level, and higher triglyceride level. The effect of GH treatment was comparable between patient groups. GH seems to protect against rising lipid levels and blood pressure, even after excluding patients using corresponding concomitant medication. The risk for cardiovascular disease or diabetes mellitus during follow-up was not different between patients with IGHD and MPHDs.ConclusionsPatients with IGHD had a less impaired metabolic profile than patients with MPHDs at baseline. Influence of other pituitary hormone replacement therapies on the effect of GH treatment is not demonstrated. |
| Databáze: | OpenAIRE |
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