Pump Speed Optimization in Stable Patients with a Left Ventricular Assist Device
Autor: | Mand J.H. Khidir, Eduard R. Holman, Lotte E. Couperus, Martin J. Schalij, Saskia L.M.A. Beeres, Robert J.M. Klautz, Laurens F. Tops, Meindert Palmen, Victoria Delgado, Marta Fiocco, Marijke P. M. Vester, Harriette F. Verwey |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Biomedical Engineering Biophysics Bioengineering 030204 cardiovascular system & hematology Biomaterials 03 medical and health sciences Hemodynamically stable 0302 clinical medicine Interquartile range Internal medicine medicine Natriuretic peptide left ventricular assist device Humans In patient 030212 general & internal medicine Aged Heart Failure business.industry Peak systolic strain General Medicine Middle Aged right ventricular function Echocardiography Ventricular assist device Rv function Cardiology Ventricular Function Right Female pump speed Heart-Assist Devices business Destination therapy |
Zdroj: | ASAIO Journal, 63(3), 266-272 |
Popis: | Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients. Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored. Hemodynamically stable patients (N = 17, age 61 [interquartile range {IQR} 51-66] years; 13 [77%] male) underwent a routine speed ramp test. Echocardiographic images were obtained at incremental speed settings to determine optimal pump speed. In 8 patients (47%), LVAD speed could be optimized. In these patients, RV fractional area change (26% [IQR 23-31] to 35% [IQR 27-45], p = 0.04) and RV longitudinal peak systolic strain (-13% [IQR -16 to -9] to -17% [IQR -18 to -11], p = 0.02) at 3 months follow-up improved without RV dilatation. Furthermore, N-terminal pro-brain natriuretic peptide level decreased (3,162 [IQR 1,336-4,487] ng/L to 2,294 [IQR 1,157-3,810] ng/L, p = 0.02). No significant follow-up changes were found in patients without indication for speed adjustment. In conclusion, routine evaluation of optimal LVAD speed reveals the potential of speed optimization in a substantial proportion of stable LVAD-DT patients and can improve RV function. |
Databáze: | OpenAIRE |
Externí odkaz: |