Low-Frequency Brain Oscillations Track Motor Recovery in Human Stroke
| Autor: | Lutz A. Krawinkel, Leonardo G. Cohen, Götz Thomalla, Jan Feldheim, Christian Gerloff, Marlene Bönstrup, Bastian Cheng, Robert Schulz |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Movement Cohort Studies 03 medical and health sciences Grip strength Animal data 0302 clinical medicine Physical medicine and rehabilitation Medicine Humans In patient Longitudinal Studies Stroke Aged Hand Strength business.industry Motor Cortex Electroencephalography Recovery of Function Middle Aged medicine.disease Brain Waves Neuromodulation (medicine) 030104 developmental biology Neurology Brain stimulation Cortical control Motor recovery Female Neurology (clinical) business 030217 neurology & neurosurgery Psychomotor Performance |
| Zdroj: | Annals of neurologyReferences. 86(6) |
| ISSN: | 1531-8249 |
| Popis: | OBJECTIVE The majority of patients with stroke survive the acute episode and live with enduring disability. Effective therapies to support recovery of motor function after stroke are yet to be developed. Key to this development is the identification of neurophysiologic signals that mark recovery and are suitable and susceptible to interventional therapies. Movement preparatory low-frequency oscillations (LFOs) play a key role in cortical control of movement. Recent animal data point to a mechanistic role of motor cortical LFOs in stroke motor deficits and demonstrate neuromodulation intervention with therapeutic benefit. Their relevance in human stroke pathophysiology is unknown. METHODS We studied the relationship between movement-preparatory LFOs during the performance of a visuomotor grip task and motor function in a longitudinal ( |
| Databáze: | OpenAIRE |
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