High levels of endothelial progenitor cells and circulating endothelial cells in patients with Behçet's disease and their relationship to disease activity
| Autor: | Deniz Aksu Arica, Burak Akşan, Asim Örem, Buket Akcan Altinkaynak, Savaş Yayli, Mehmet Sönmez |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Vasculitis Endothelial cells CD34 Cell Count Dermatology Behcet's disease Flow cytometry Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Progenitor cell Endothelial dysfunction Matrix Metalloproteinase-9 Endothelial Progenitor Cells Investigation medicine.diagnostic_test Behçet's disease business.industry Behcet Syndrome General Medicine Middle Aged medicine.disease Flow Cytometry Vascular endothelial growth factor Vascular endothelial growth factor A C-Reactive Protein Cross-Sectional Studies chemistry RL1-803 030220 oncology & carcinogenesis Case-Control Studies Cancer research Female business Biomarkers |
| Zdroj: | Anais Brasileiros de Dermatologia Anais Brasileiros de Dermatologia v.94 n.3 2019 Anais brasileiros de dermatologia Sociedade Brasileira de Dermatologia (SBD) instacron:SBD Anais Brasileiros de Dermatologia, Volume: 94, Issue: 3, Pages: 320-326, Published: 29 JUL 2019 Anais Brasileiros de Dermatologia, Vol 94, Iss 3, Pp 320-326 (2019) |
| ISSN: | 1806-4841 |
| Popis: | Background: Behçet's disease is a multisystemic vasculitis, associated with vascular endothelial dysfunction. Currently, the prognosis is unpredictable, because there is still no valid laboratory marker indicating the disease activity in Behçet's disease. Endothelial progenitor cells and circulating endothelial cells are newly introduced hematological markers which are presumed to take part in the pathogenesis of vasculitis. Objectives: To evaluate the levels of endothelial progenitor cells and subtypes and circulating endothelial cells in patients with Behçet's disease and to describe their relationship with the disease activity. Methods: A total of 45 patients with Behçet's disease and 28 healthy controls were included in the study. Endothelial progenitor cells (CD34+CD133+KDR+ as early endothelial progenitor cells and CD34+KDR+ as late endothelial progenitor cells), and circulating endothelial cells (CD34+CD133+) were measured by flow cytometry. Results: The mean plasma level of endothelial progenitor cells and circulating endothelial cells, vascular endothelial growth factor, matrix metalloproteinase-9, C-reactive protein, and erythrocyte sedimentation rate were significantly higher in patients with Behçet's disease. All of these parameters except circulating endothelial cells were also found to be higher in patients with active disease than in patients with inactive disease. Early endothelial progenitor cells showed significant correlations with C-reactive protein and circulating endothelial cells. Study Limitations: The cross-sectional nature of the study and patient characteristics such as being under treatment, which can affect endothelial progenitor cells numbers. Conclusion: The increase in endothelial progenitor cells may play an essential role in the repair of endothelial injury in Behçet's disease, especially in the active period of the disease. Thus, endothelial progenitor cells can indicate the disease activity. In addition, endothelial progenitor cells and circulating endothelial cells can be used as endothelial repair and injury markers for Behçet's disease, respectively. |
| Databáze: | OpenAIRE |
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