Parathyroid Function after Total Thyroidectomy: A Randomized Clinical Trial Concerning the Influence of the Surgical Technique
| Autor: | Olympia Anastasiou, S. Panidis, Ioannis Pliakos, Theodossis S. Papavramidis, Antonios Michalopoulos, George Kotsovolis |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Organs at Risk medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Medizin Urology Parathyroid hormone 030230 surgery law.invention Diagnostic Techniques Endocrine Parathyroid Glands 03 medical and health sciences chemistry.chemical_compound Postoperative Complications 0302 clinical medicine Endocrinology Randomized controlled trial law Harmonic scalpel Humans Medicine Endocrine system Postoperative Period Vitamin D Aged Total thyroidectomy Sodium bicarbonate business.industry Thyroidectomy General Medicine Middle Aged Surgery Sodium Bicarbonate chemistry Parathyroid Hormone 030220 oncology & carcinogenesis Calcium Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine Practice. 24:150-155 |
| ISSN: | 1530-891X |
| DOI: | 10.4158/ep-2017-0100 |
| Popis: | Thyroidectomy impairs parathyroid function, even if it does not necessarily lead to postoperative clinical hypocalcemia. This study was prospective and evaluated the parathyroid hormone (PTH) function in nonclinically symptomatic patients after total thyroidectomy performed by two different techniques.Prospective randomized clinical trial including 269 patients undergoing classic or harmonic scalpel total thyroidectomy. Pre-operatively and at 48 hours, biochemical analysis was performed. Simultaneously, a sodium bicarbonate test (SBT) was performed.Calcium and PTH were altered for both groups ( P.001). During SBT at 3 minutes after infusion, PTH rose and reached its maximum for both groups ( P.001) and then decreased at 5 minutes ( P.001 and P = .004) and at 10 minutes ( P = .006 and P = .043) before returning to baseline levels. At 5 and 10 minutes of the SBT, some differences were observed between the groups. The difference in clinically obvious parathyroid dysfunction between groups was not significant, but there was a difference in the peak PTH levels after bicarbonate stimulation. Similarly, total secretion during the test, as well as total secretion for the first 10 minutes, was practically the same for the two groups. Additionally, partial subclinical postoperative hypoparathyroidism was clearly more common in the harmonic scalpel thyroidectomy group ( P.001).SBT demonstrated more impairment in the harmonic scalpel group, as parathyroid function was altered after thyroidectomy.HSTT = harmonic scalpel total thyroidectomy PTH = parathyroid hormone SBIT = sodium bicarbonate infusion test. |
| Databáze: | OpenAIRE |
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