Gastrointestinal hemodynamic changes during therapeutic hypothermia and after rewarming in neonatal hypoxic-Ischemic encephalopathy
| Autor: | Annie Lapointe, Jesal N. Sheth, Aideen M. Moore, Patrick J. McNamara, Amish Jain, Pankaj Sakhuja, Kiran More, Joseph Ting |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Encephalopathy Hemodynamics Gestational Age Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Celiac artery Celiac Artery Hypothermia Induced 030225 pediatrics Internal medicine medicine.artery medicine Humans 030212 general & internal medicine Prospective Studies Rewarming business.industry Infant Newborn lcsh:RJ1-570 Gestational age lcsh:Pediatrics Blood flow Hypothermia medicine.disease Echocardiography Doppler Mesenteric Arteries Gastrointestinal Tract medicine.anatomical_structure Ventricle Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain Cardiology Female medicine.symptom business Blood Flow Velocity Artery |
| Zdroj: | Pediatrics and Neonatology, Vol 60, Iss 6, Pp 669-675 (2019) |
| ISSN: | 1875-9572 |
| Popis: | Background: Hypoxic-ischemic encephalopathy (HIE) is associated with disturbances in visceral blood flow velocities. Therapeutic Hypothermia (TH) is a standard of care; however, its impact on gastrointestinal blood flow in infants with HIE is unknown. The objective of this study was to assess gastrointestinal (GI) blood flow and left ventricle output (LVO) in infants with hypoxic-ischemic encephalopathy during whole body TH and after rewarming. Methods: Serial echocardiography and Doppler evaluation of intestinal blood flow (celiac (CA) and superior mesenteric (SMA) arteries) were prospectively performed in a cohort of 20 newborn infants with HIE at 4 time points during hypothermia and after rewarming. Demographic, clinical and biochemical data were collected and analyzed for their relevance. Results: Median gestational age and birth weight was 40 weeks (37–41) and 3410 g (2190–4950) respectively. Celiac and mesenteric artery flow remained low during hypothermia and rose significantly after rewarming [peak systolic velocity in CA (0.63 m/s to 0.77 m/s, p = 0.004) and SMA (0.43 m/s to 0.55 m/s, p = 0.001)]. This increase was temporally associated with increased left ventricular output (106 ml/kg/min to 149 ml/kg/min, p |
| Databáze: | OpenAIRE |
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