Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications
Autor: | Rodolfo Citro, Jelena R. Ghadri, Guido Grassi, Liam Couch, Eduardo Bossone, Thomas Thum, Guido Parodi, Bastian Bruns, Christian Templin, Stephane Heymans, Ovidiu Chioncel, Elmir Omerovic, Birke Schneider, Jolanda van der Velden, C. Gabriele Tocchetti, Dana Dawson, Massimo Iacoviello, Johannes Backs, Alexander R. Lyon, Michele Ciccarelli, Björn Redfors |
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Přispěvatelé: | Omerovic, E., Citro, R., Bossone, E., Redfors, B., Backs, J., Bruns, B., Ciccarelli, M., Couch, L. S., Dawson, D., Grassi, G., Iacoviello, M., Parodi, G., Schneider, B., Templin, C., Ghadri, J. R., Thum, T., Chioncel, O., Tocchetti, C. G., Van Der Velden, J., Heymans, S., Lyon, A. R., Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H02 Cardiomyopathy, Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, L, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, J, Thum, T, Chioncel, O, Tocchetti, C, Van Der Velden, J, Heymans, S, Lyon, A, University of Zurich, Omerovic, Elmir, Lyon, Alexander R |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Nervous system
Sympathetic nervous system Cardiac & Cardiovascular Systems TAKO-TSUBO CARDIOMYOPATHY COUPLED RECEPTOR KINASE-5 DIAGNOSTIC-CRITERIA Cardiology 610 Medicine & health Pathophysiology 2705 Cardiology and Cardiovascular Medicine EMOTIONAL-STRESS Oestrogen Genetic Takotsubo Cardiomyopathy STRESS-INDUCED CARDIOMYOPATHY Vascular RAT MODEL CATECHOLAMINE Cardiovascular problems Genetics Humans Medicine Gonadal Steroid Hormones Heart Failure Takotsubo syndrome Science & Technology microRNA business.industry Inducible pluripotent stem cell model medicine.disease NERVOUS-SYSTEM Cardiovascular physiology MicroRNAs Inducible pluripotent stem cell models medicine.anatomical_structure MODEL REVEALS Heart failure 10209 Clinic for Cardiology Cardiovascular System & Cardiology Cardiology and Cardiovascular Medicine business FOLLOW-UP Life Sciences & Biomedicine Hormone |
Zdroj: | European journal of heart failure, 24(2), 274-286. Wiley |
ISSN: | 1388-9842 |
Popis: | While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research. ispartof: EUROPEAN JOURNAL OF HEART FAILURE vol:24 issue:2 pages:274-286 ispartof: location:England status: published |
Databáze: | OpenAIRE |
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