Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

Autor: Rodolfo Citro, Jelena R. Ghadri, Guido Grassi, Liam Couch, Eduardo Bossone, Thomas Thum, Guido Parodi, Bastian Bruns, Christian Templin, Stephane Heymans, Ovidiu Chioncel, Elmir Omerovic, Birke Schneider, Jolanda van der Velden, C. Gabriele Tocchetti, Dana Dawson, Massimo Iacoviello, Johannes Backs, Alexander R. Lyon, Michele Ciccarelli, Björn Redfors
Přispěvatelé: Omerovic, E., Citro, R., Bossone, E., Redfors, B., Backs, J., Bruns, B., Ciccarelli, M., Couch, L. S., Dawson, D., Grassi, G., Iacoviello, M., Parodi, G., Schneider, B., Templin, C., Ghadri, J. R., Thum, T., Chioncel, O., Tocchetti, C. G., Van Der Velden, J., Heymans, S., Lyon, A. R., Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H02 Cardiomyopathy, Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, L, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, J, Thum, T, Chioncel, O, Tocchetti, C, Van Der Velden, J, Heymans, S, Lyon, A, University of Zurich, Omerovic, Elmir, Lyon, Alexander R
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Nervous system
Sympathetic nervous system
Cardiac & Cardiovascular Systems
TAKO-TSUBO CARDIOMYOPATHY
COUPLED RECEPTOR KINASE-5
DIAGNOSTIC-CRITERIA
Cardiology
610 Medicine & health
Pathophysiology
2705 Cardiology and Cardiovascular Medicine
EMOTIONAL-STRESS
Oestrogen
Genetic
Takotsubo Cardiomyopathy
STRESS-INDUCED CARDIOMYOPATHY
Vascular
RAT MODEL
CATECHOLAMINE
Cardiovascular problems
Genetics
Humans
Medicine
Gonadal Steroid Hormones
Heart Failure
Takotsubo syndrome
Science & Technology
microRNA
business.industry
Inducible pluripotent stem cell model
medicine.disease
NERVOUS-SYSTEM
Cardiovascular physiology
MicroRNAs
Inducible pluripotent stem cell models
medicine.anatomical_structure
MODEL REVEALS
Heart failure
10209 Clinic for Cardiology
Cardiovascular System & Cardiology
Cardiology and Cardiovascular Medicine
business
FOLLOW-UP
Life Sciences & Biomedicine
Hormone
Zdroj: European journal of heart failure, 24(2), 274-286. Wiley
ISSN: 1388-9842
Popis: While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research. ispartof: EUROPEAN JOURNAL OF HEART FAILURE vol:24 issue:2 pages:274-286 ispartof: location:England status: published
Databáze: OpenAIRE