Immune response in colorectal carcinoma: a review of its significance as a predictive and prognostic biomarker

Autor:	Phoenix D Bell, Reetesh K Pai
Rok vydání:	2022
Předmět:	Lymphocytes Tumor-Infiltrating Histology Immunity Humans Lymphocyte Count General Medicine CD8-Positive T-Lymphocytes Prognosis Colorectal Neoplasms Pathology and Forensic Medicine
Zdroj:	Histopathology. 81:696-714
ISSN:	1365-2559 0309-0167
DOI:	10.1111/his.14713
Popis:	Colorectal carcinoma is a leading cause of cancer-related death worldwide. There is significant prognostic heterogeneity in stages II and III tumours, necessitating the development of new biomarkers to more clearly identify patients at risk of disease progression. Recently, the tumour immune environment, particularly the type and quantity of T lymphocytes, has been shown to be a useful biomarker in predicting prognosis for patients with colorectal carcinoma. In this review, the significance of the immune response in colorectal carcinoma, including its influence on prognosis and response to therapy, will be detailed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2c8e36695ad9b0fc1fc13d8c43a666 https://doi.org/10.1111/his.14713 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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