Feasibility of MDCT Colonography in Ultra-Low-Dose Technique in the Detection of Colorectal Lesions: Comparison with High-Resolution Video Colonoscopy
| Autor: | Mathias Cohnen, Wolfram Heinen, Kjel Andersen, A. Beck, Volker Aurich, Ulrich Moedder, C. Vogt, Dieter Haeussinger, Stephan vom Dahl |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Supine position Ultra low dose Colon Colonic Polyps High resolution Colonoscopy Radiation Dosage Ct dose index Sensitivity and Specificity Predictive Value of Tests medicine Humans False Positive Reactions Radiology Nuclear Medicine and imaging Bowel cleansing False Negative Reactions medicine.diagnostic_test business.industry Low dose General Medicine Middle Aged Endoscopy Female Radiology Colorectal Neoplasms business Colonography Computed Tomographic |
| Zdroj: | American Journal of Roentgenology. 183:1355-1359 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.183.5.1831355 |
| Popis: | The purpose of this study was to assess the feasibility of MDCT colonography in an ultra-low-dose technique in the detection of endoluminal colonic lesions compared with high-resolution video colonoscopy.After standard bowel cleansing, 137 patients (77 men, 60 women; mean [+/- SD] age, 57.1 +/- 11.3 years) underwent high-resolution video colonoscopy within 2 hr after ultra-low-dose MDCT colonography had been performed. Ultra-low-dose MDCT colonography was performed with patients in the supine position only using 10 mAs (effective weighted CT dose index, 0.94 mGy). After mathematic noise reduction by nonlinear gaussian filter chains, using dedicated software (ECCET), images were analyzed by two blinded observers in simultaneously displayed interactive 2D and 3D modes. Findings of ultra-low-dose MDCT colonography were compared with the results obtained with high-resolution video colonoscopy.Calculated effective doses were 0.7 and 1.2 mSv for men and women, respectively. Ultra-low-dose MDCT colonography detected 84 (62%) of 135 lesions: 11 (78.6%) of 14 large polyps (10 mm), 12 (85.7%) of 14 medium polyps (9.9-5 mm), and 61 (57%) of 107 small polyps (5 mm). On a patient-by-patient basis, an overall sensitivity of 70.3% with a specificity of 80.8% was calculated. False-positive findings were seen mostly for small lesions (eight medium and 29 small lesions). Two of the three false-negative lesions were retrospectively detected in contrast-enhanced cleansing fluid; one was a flat lipoma not detectable on ultra-low-dose MDCT colonography.Despite an effective dose of approximately 1 mSv, MDCT colonography using an ultra-low-dose technique performs as well as MDCT colonography with a standard dose, according to published data. After mathematic noise reduction, 82% of polyps larger than 5 mm can be detected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|