Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy
| Autor: | Hiroyuki Shimizu, Noriyuki Sato, Yutaka Uehara, Kikuo Kasai, Yohnosuke Shimomura, Mayumi Negishi, Kenju Shimomura, Masatomo Mori, Miki Masunaga |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Diet Reducing Diet therapy Endocrinology Diabetes and Metabolism food.diet media_common.quotation_subject Receptors Cell Surface Peptide hormone Body Mass Index food Japan Internal medicine medicine Humans Obesity Menstrual Cycle Menstrual cycle media_common Nutrition and Dietetics Leptin receptor business.industry medicine.disease Very low calorie diet Endocrinology Receptors Leptin Female Carrier Proteins business Hormone |
| Zdroj: | Nutrition. 18:309-312 |
| ISSN: | 0899-9007 |
| DOI: | 10.1016/s0899-9007(01)00787-0 |
| Popis: | Concentrations of the soluble leptin receptor (sOB-R) may be related to leptin resistance in obesity. We measured sOB-R concentrations in serum in 103 non-diabetic Japanese men and women. All subjects were grouped according to body mass index (BMI; in kg/m(2)). Serum sOB-R concentrations did not differ significantly between normal-weight (18.5or = BMI25.0) men and women, but were significantly higher in underweight subjects (BMI18.5) than in normal-weight subjects. In contrast, overweight (25or = BMI30) and obese (30or = BMI35.0, 35.0or = BMI40, and BMIor = 40) subjects had significantly lower sOB-R concentrations than did normal-weight subjects. Serum sOB-R concentrations were inversely correlated with BMI and serum immunoreactive leptin concentrations. Very low-energy diet therapy for 4 wk significantly lowered serum immunoreactive leptin concentrations but did not significantly affect serum sOB-R concentrations. Serum sOB-R concentrations did not change significantly during the menstrual cycle. Our results showed that serum sOB-R concentrations decrease with increasing BMI and that sex hormones likely do not affect serum sOB-R concentrations in non-pregnant women. The reduction in serum sOB-R concentrations in overweight and obese persons may reflect downregulation of hypothalamic leptin receptor production as a result of an increase in circulating leptin and might be an important factor in leptin resistance. |
| Databáze: | OpenAIRE |
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