Altered functional connectivity in the fear network of firefighters with repeated traumatic stress
| Autor: | Eun Hee Lee, Jiyoung Ma, Eunji Ha, Haejin Hong, Jungyoon Kim, Stephen R. Dager, Shinwon Park, Hyeonseok S. Jeong, Young Sun Hong, Ilhyang Kang, Ji-Eun Kim, In Kyoon Lyoo, Soo Mee Lim, Sujung Yoon, Suji L. Lee |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Stress Disorders Traumatic medicine.medical_specialty Ventromedial prefrontal cortex Prefrontal Cortex Poison control Audiology Hippocampus Amygdala 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Anterior cingulate cortex medicine.diagnostic_test business.industry Functional Neuroimaging Traumatic stress Fear Human brain Middle Aged 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Firefighters Female Nerve Net Functional magnetic resonance imaging business Insula |
| Zdroj: | The British Journal of Psychiatry. 214:347-353 |
| ISSN: | 1472-1465 0007-1250 |
| Popis: | BackgroundFirefighters are routinely exposed to various traumatic events and often experience a range of trauma-related symptoms. Although these repeated traumatic exposures rarely progress to the development of post-traumatic stress disorder, firefighters are still considered to be a vulnerable population with regard to trauma.AimsTo investigate how the human brain responds to or compensates for the repeated experience of traumatic stress.MethodWe included 98 healthy firefighters with repeated traumatic experiences but without any diagnosis of mental illness and 98 non-firefighter healthy individuals without any history of trauma. Functional connectivity within the fear circuitry, which consists of the dorsal anterior cingulate cortex, insula, amygdala, hippocampus and ventromedial prefrontal cortex (vmPFC), was examined using resting-state functional magnetic resonance imaging. Trauma-related symptoms were evaluated using the Impact of Event Scale – Revised.ResultsThe firefighter group had greater functional connectivity between the insula and several regions of the fear circuitry including the bilateral amygdalae, bilateral hippocampi and vmPFC as compared with healthy individuals. In the firefighter group, stronger insula–amygdala connectivity was associated with greater severity of trauma-related symptoms (β = 0.36, P = 0.005), whereas higher insula–vmPFC connectivity was related to milder symptoms in response to repeated trauma (β = −0.28, P = 0.01).ConclusionsThe current findings suggest an active involvement of insular functional connectivity in response to repeated traumatic stress. Functional connectivity of the insula in relation to the amygdala and vmPFC may be potential pathways that underlie the risk for and resilience to repeated traumatic stress, respectively.Declaration of interestNone. |
| Databáze: | OpenAIRE |
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