15-HETE inhibits leukotriene B4 formation and synovial cell proliferation in experimental arthritis
| Autor: | V. E. Knudsen, Troels Herlin, K. Fogh, Ebbe Stender Hansen, Knud Kragballe, A. Andreasen, Tine Brink Henriksen, Cody Bünger |
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| Rok vydání: | 1990 |
| Předmět: |
Immunology
Arthritis Endogeny In Vitro Techniques Pharmacology Carrageenan Toxicology Leukotriene B4 Proinflammatory cytokine chemistry.chemical_compound Dogs Hydroxyeicosatetraenoic Acids Synovial Fluid Cell Adhesion medicine Animals Synovial fluid Pharmacology (medical) Cells Cultured chemistry.chemical_classification hemic and immune systems Chemotaxis medicine.disease Arthritis Experimental Enzyme chemistry Synovial Cell lipids (amino acids peptides and proteins) Arachidonic acid Cell Division circulatory and respiratory physiology |
| Zdroj: | Herlin, T, Fogh, K, Hansen, E S, Andreasen, A, Knudsen, V, Henriksen, T B, Bünger, C & Kragballe, K 1990, ' 15-HETE inhibits leukotriene B4 formation and synovial cell proliferation in experimental arthritis ', Agents and actions, vol. 29, no. 1-2, pp. 52-3 . |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01964718 |
| Popis: | Leukotriene B 4 (LTB4) is formed by the 5-1ipoxygenase (5-LO) pathway of arachidonic acid (AA) metabolism. LTB4 is a potent stimulator of neutrophil function and in carragheenan induced arthritis we have previously demonstrated an accumulation of LTB4 in the synovial fluid [1]. 15-hydroxy-eicosatetraenoic acid (15-HETE), being a product of AA generated via the 15-LO enzyme, is not proinflammatory but inhibits 5-LO and 12-LO activity [2] and LTB4-induced chemotaxis [3]. In the present study we have shown that carragheenan induced arthritis was inhibited by intraarticular injections with the endogenous 5-LO inhibitor, 15-HETE. |
| Databáze: | OpenAIRE |
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