Proactive maintenance therapy of canine atopic dermatitis with the anti‐IL ‐31 lokivetmab. Can a monoclonal antibody blocking a single cytokine prevent allergy flares?
| Autor: | Thierry Olivry, Chie Tamamoto-Mochizuki, Judy S. Paps |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Allergy 040301 veterinary sciences medicine.drug_class medicine.medical_treatment Disease Monoclonal antibody Gastroenterology 0403 veterinary science 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine House dust mite General Veterinary biology business.industry 04 agricultural and veterinary sciences Atopic dermatitis biology.organism_classification medicine.disease Regimen Cytokine business Skin lesion |
| Zdroj: | Veterinary Dermatology. 30:98-e26 |
| ISSN: | 1365-3164 0959-4493 |
| Popis: | Background Once the signs of canine atopic dermatitis (AD) are controlled, the proactive application of topical glucocorticoids can delay disease flares. Objectives We wished to determine if the proactive administration of the anti-IL-31 lokivetmab would prevent or delay flares of canine AD. Animals We tested this strategy in four Maltese-beagle atopic dogs before enrolling 21 dogs with spontaneous AD. Methods and materials In our acute AD model, house dust mite (HDM)-sensitized dogs were injected once with lokivetmab. After seven days, an HDM suspension was applied epicutaneously, and both skin lesions and pruritus manifestations were quantified for 24 h. In a second study, 21 dogs with spontaneous AD controlled with anti-allergic drugs were treated with lokivetmab per manufacturer's recommendations; all anti-allergic drugs were discontinued within four weeks after the first injection. All dogs were followed prospectively for at least one year and the time-to-flare (TTF) of AD after the last day of anti-allergic treatment was determined. Results In the experimental study, one injection of lokivetmab prevented nearly all expected allergen-induced pruritus manifestations but not skin lesion development. In dogs with spontaneous AD, the median TTF after lokivetmab proactive therapy was 63 days. One-fourth of dogs did not exhibit a flare for at least one year while receiving lokivetmab monotherapy. Conclusions Although lokivetmab seems more effective to prevent pruritus than skin lesions in dogs with experimental AD' it also can delay disease flares in some dogs with the spontaneous disease. Studies are needed to identify those patients most likely to respond to such a proactive regimen. |
| Databáze: | OpenAIRE |
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