Central respiratory effects of substance P in neonatal mice: an in vitro study

Autor: Krzysztof Ptak, Gérard Hilaire
Přispěvatelé: Dumonceaud, Corinne, Groupe d'étude des réseaux moteurs - GERM (GERMG), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 1999
Předmět:
MESH: Phrenic Nerve
MESH: Substance P
Substance P
MESH: Animals
Newborn
MESH: Spinal Cord
Mice
chemistry.chemical_compound
0302 clinical medicine
MESH: Animals
Respiratory system
Receptor
[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
Phrenic nerve
Mice
Inbred C3H
0303 health sciences
Respiration
General Neuroscience
Anatomy
3. Good health
Phrenic Nerve
medicine.anatomical_structure
Spinal Cord
MESH: Neck
Agonist
medicine.medical_specialty
MESH: Rats
Respiratory rate
MESH: Mice
Transgenic
medicine.drug_class
Central nervous system
Mice
Transgenic
In Vitro Techniques
03 medical and health sciences
Species Specificity
Internal medicine
medicine
MESH: Species Specificity
Animals
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
MESH: Mice
Inbred C3H
MESH: Mice
030304 developmental biology
MESH: Respiration
business.industry
Rats
Endocrinology
Monoamine neurotransmitter
Animals
Newborn
chemistry
MESH: Brain Stem
business
Neck
030217 neurology & neurosurgery
Brain Stem
Zdroj: Neuroscience Letters
Neuroscience Letters, Elsevier, 1999, 266 (3), pp.189-92
Neuroscience Letters, 1999, 266 (3), pp.189-92
ISSN: 0304-3940
DOI: 10.1016/s0304-3940(99)00289-x
Popis: Experiments were performed on neonatal mice to know whether substance P (SP) modified the rhythm and the amplitude of the phrenic bursts generated in vitro in brainstem-cervical cord preparations. In OF1 and C3H neonatal preparations, SP or the tachykinin NK1 receptor agonist [Sar9,Met(O2)11] substance P both increased significantly phrenic burst amplitude (10(-7) M) but had no significant effect on respiratory rhythm unless used at concentrations 10 times larger. In neonates from the monoamine oxidase-A deficient transgenic Tg8 line, SP increased phrenic burst amplitude but had no effect on the respiratory rhythm at the tested concentrations. The role of SP in regulating neonatal respiratory activity is discussed on the basis of rat and mouse results.
Databáze: OpenAIRE
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