Expression of transforming growth factor-beta 1 in human bladder cancer
| Autor: | Soichiro Torigoe, Yoshinobu Kubota, Yasushi Dobashi, Hiroshi Miyamoto, Masahiko Hosaka, Taro Shuin |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Transcription Genetic Urinary Bladder urologic and male genital diseases Polymerase Chain Reaction Epithelium Tumor Cells Cultured medicine Humans Neoplasm Invasiveness RNA Neoplasm Intermediate Grade Lymphotoxin-alpha Aged Neoplasm Staging Tumor marker Carcinoma Transitional Cell Bladder cancer Urinary bladder biology business.industry Cancer Transforming growth factor beta medicine.disease Actins Gene Expression Regulation Neoplastic Transitional cell carcinoma medicine.anatomical_structure Urinary Bladder Neoplasms Oncology Tumor progression Carcinoma Squamous Cell biology.protein Cancer research Female Neoplasm Recurrence Local business |
| Zdroj: | Cancer. 75:2565-2570 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19950515)75:10<2565::aid-cncr2820751025>3.0.co;2-m |
| Popis: | Background. Elevated expression of transforming growth factor-beta 1 (TGF-βl) has been reported in several types of human cancer. However, the significance of TGF-β1 expression in clinical bladder cancer is not well known. Methods. The levels of TGF-β1 expression were quantitated using a polymerase chain reaction-based method in tissue specimens obtained from 51 patients with bladder cancer. Results. Transforming growth factor-beta 1 expression in bladder cancer was higher than that found in normal bladder epithelium (P < 0.01). Significantly higher levels of TGF-β1 transcripts were observed in low and intermediate grade (Grade 1 and 2) tumors than in high grade (Grade 3) tumors (P < 0.02). Superficial (pTa and pT1) tumors had higher levels of TGF-β1 than invasive (pT2 or higher) tumors (P < 0.05). Conclusions. These results suggest that enhanced expression of TGF-β1 is specific to low grade and stage bladder cancer. Transforming growth factor-beta 1 may play an important role in the early stages of human bladder cancer development, and TGF-β1 expression could provide a new relevant tumor marker for determining tumor progression in patients with bladder cancer. Cancer 1995 ;75 :2565-70. |
| Databáze: | OpenAIRE |
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