Fluorine-18-fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an endemic goiter area
| Autor: | Ewald Kresnik, I. Gomez, Hans J. Gallowitsch, G. Kumnig, Isabella Igerc, Peter Mikosch, Peter Lind, Haro Stettner |
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| Rok vydání: | 2003 |
| Předmět: |
Adenoma
Adult Male Thyroid nodules endocrine system Goiter endocrine system diseases Diagnosis Differential Thyroid carcinoma Fluorodeoxyglucose F18 Predictive Value of Tests Preoperative Care Carcinoma Humans Medicine Thyroid Neoplasms Thyroid Nodule Thyroid cancer Aged medicine.diagnostic_test business.industry Thyroid Middle Aged medicine.disease medicine.anatomical_structure Positron emission tomography Austria Female Surgery Radiopharmaceuticals business Nuclear medicine Goiter Endemic Tomography Emission-Computed |
| Zdroj: | Surgery. 133:294-299 |
| ISSN: | 0039-6060 |
| Popis: | The aim of this study was to evaluate the usefulness of fluorine-18-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in the preoperative assessment of suspicious thyroid nodules.A total of 43 patients were examined before surgical resection. In all patients, imaging was obtained at 70 minutes after the intravenous administration of 180 MBq (18)F-FDG. Standard uptake values (SUVs) were calculated.A total of 16 patients with thyroid carcinomas (11 papillary, 3 follicular, 2 anaplastic), 23 thyroid adenomas (11 microfollicular, 10 Hurthle cell, 2 macrofollicular), and 4 patients with degenerative goiter were found. (18)F-FDG uptake in Hurthle cell adenoma, thyroid cancer, microfollicular adenoma, degenerative goiter, and macrofollicular adenoma was 4.4 +/- 2.2, 3.7 +/- 1.9, 1.6 +/- 0.3, 1.2 +/- 0.2, and 0.9 +/- 0.1, respectively. Significant differences were observed between thyroid carcinomas and both microfollicular adenomas and degenerative goiters (P0.05), and between Hurthle cell adenomas and both microfollicular adenomas as well as degenerative goiter (P0.05). For diagnosis of thyroid carcinoma, 100% sensitivity, 63% specificity, and 100% negative predictive value was found when a cutoff value for SUV of 2 was used.Our results indicate that thyroid carcinomas, in contrast to most benign thyroid nodules, demonstrate significantly increased glucose metabolism. (18)F-FDG PET is unlikely to differentiate successfully all benign tumors from malignant tumors, but it can help select patients who need surgery, especially if cytology is inconclusive or malignancy cannot be excluded. |
| Databáze: | OpenAIRE |
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