Subacute inhalation exposure of rats to 1,6-hexamethylene diisocyanate with recovery period

Autor:	David W. Sturdivant, Barry Stuart, Herbert Hoss, Ghona K. Sangha, Ronald N. Shiotsuka
Rok vydání:	2006
Předmět:	Male Urinalysis Health Toxicology and Mutagenesis Physiology Acanthosis Air Pollutants Occupational Toxicology medicine.disease_cause Turbinates Rats Sprague-Dawley chemistry.chemical_compound Administration Inhalation medicine Animals Cyanates Inhalation exposure Inhalation Exposure No-Observed-Adverse-Effect Level medicine.diagnostic_test Inhalation Dose-Response Relationship Drug Chemistry Recovery of Function medicine.disease Rats Nasal Mucosa medicine.anatomical_structure Withholding Treatment Anesthesia Toxicity Hexamethylene diisocyanate Female Irritation Nasal Cavity Respiratory tract Isocyanates
Zdroj:	Inhalation toxicology. 18(9)
ISSN:	1091-7691
Popis:	In this subacute inhalation toxicity study of 1,6-hexamethylene diisocyanate (HDI), groups of 10 male and 10 female Sprague-Dawley rats were exposed to 0, 0.005, 0.0175, or 0.150 ppm HDI vapor, 5 h/day, 5 days/wk for 15 exposure days and included animals sacrificed 2 wk postexposure. The purpose was to characterize the HDI-induced effects and their reversibility, and to determine a no-observed-adverse-effect level (NOAEL). No compound-related effects were found for body weights, clinical chemistry, urinalysis, hematology, and organ weights. Thus, no evidence of systemic toxicity was found in this study. The exposure-related findings were restricted to the portal of entry, the respiratory tract. Transient signs of sensory irritation were observed after the daily exposure periods, but the principal findings were the histopathologic changes of the nasal epithelium. Generally, an anterior to posterior gradient of incidence and severity was found, and the changes were characterized as acanthosis, erosion, hyperkeratosis, epithelial cell hyperplasia, chronic active inflammation, squamous metaplasia, ulceration, transitional epithelial cell degeneration, goblet-cell hyperplasia, and degeneration of the olfactory epithelium. Varying degrees of concordance between exposure concentration and incidence and/or severity of the histopathologic changes were found. During a 2-wk recovery period, a tendency toward recovery was evident for tissue changes in the nasal cavity. A NOAEL of 0.0175 ppm HDI was determined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac25f03e4a8d9b3906d663fb69ca5df4 https://pubmed.ncbi.nlm.nih.gov/16864556 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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