False Positive Tumor Markers: Elevation in Patients with Breast Cancer on FAC-type Chemotherapy and Correlation with the Development of Hand-foot Syndrome
| Autor: | G. K. Ellis, G. M. Longton, R. B. Livingston, Leanna Tyshler |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Pathology medicine.medical_treatment Clinical Biochemistry Mammary gland Breast Neoplasms Malignancy Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Carcinoma Humans Antigens Tumor-Associated Carbohydrate False Positive Reactions Cyclophosphamide Tumor marker Chemotherapy Foot business.industry Mucin-1 Hand medicine.disease Carcinoembryonic Antigen Regimen 030104 developmental biology medicine.anatomical_structure Doxorubicin 030220 oncology & carcinogenesis Female Drug Eruptions Fluorouracil False positive rate Neoplasm Recurrence Local business |
| Zdroj: | The International Journal of Biological Markers. 11:203-206 |
| ISSN: | 1724-6008 |
| DOI: | 10.1177/172460089601100404 |
| Popis: | Breast cancer patients on dose-intensive chemotherapy often have elevated tumor markers during the course of treatment. Our objective was to estimate the incidence of a “false positive” tumor marker screen and to determine whether hand-foot epithelial damage was correlated. Data from 53 patients with high risk primary breast cancer who had undergone adjuvant or neoadjuvant 5FU-containing chemotherapy (FAC or FAC plus G-CSF) for 3 to 12 months were reviewed. The relationship between tumor marker elevation and disease recur- rence, regimen intensity, and the occurrence of hand-foot syndrome was examined. Thirty-three of the 53 patients had elevated tumor markers in the absence of recurrent disease. The false positive rate was higher in patients who underwent FAC plus G-CSF chemotherapy than in patients who underwent FAC chemotherapy (92% vs 55%, p = .01). A false positive marker screen was associated with the occurrence of hand-foot syndrome even when the effect of regimen was accounted for by stratification (p=.01). Tumor marker screening of breast cancer patients on this type of adjuvant chemotherapy has poor specificity for recurrent malignancy. These data suggest tumor marker elevation may be an indicator of epithelial toxicity during chemotherapy, manifested clinically as hand-foot syndrome. |
| Databáze: | OpenAIRE |
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