Potencial of different hydroxyapatites as biomaterials in the bone remodeling
| Autor: | Marco Antônio Utrera Martines, Iandara Schettert Silva, Osmar Ignácio Ayala, Luciane Candeloro Portugual, Claudio Goncalves de Oliveira, Ruy de Araujo Caldas, Pedro Carvalho Cassino, Larissa Schimidt Rosseti |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty RD1-811 Biocompatibility Biocompatible Materials 02 engineering and technology Bone remodeling Neovascularization 03 medical and health sciences Materials Testing medicine Animals Hydroxyapatites Tibia Rats Wistar Hyaline cartilage Chemistry 021001 nanoscience & nanotechnology Rats 030104 developmental biology medicine.anatomical_structure Durapatite Strontium Bone Substitutes Surgery Histopathology Bone marrow Bone Remodeling medicine.symptom 0210 nano-technology Biomedical engineering |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 33, Issue: 9, Pages: 816-823, Published: SEP 2018 Acta Cirúrgica Brasileira v.33 n.9 2018 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Vol 33, Iss 9, Pp 816-823 (2018) |
| Popis: | Purpose: To analyze the therapeutic potentials of different hydroxyapatites used for the correction of bone defects in rats. Methods: Forty rats, male, albino wistar, were distributed in 4 groups. They were submitted to a 3.5 mm defect in tibia. They received low purity hydroxyapatite, Strontium hydroxyapatite and hydroxyapatite doped with gallium, having a seven day evaluation time. Histopathology slides were stained with hematoxylin-eosin, for morphological evaluation. Were analyzed inflammatory processes, necrosis, presence of osteoclasts and osteoblasts, presence of the material, presence of white cells, neovascularization and bone neoformation. Results: It was observed that the groups HAPSr and HAPGa, presented better results of trabecular bone, hyaline cartilage and bone marrow more organized. Conclusion: There was improvement in the repair of the bone defect produced, showing that these hydroxyapatites are effective osteoinductive, osteoconductive, osteintegrant agents and have biocompatibility, and may be indicated for use in defect repairs. |
| Databáze: | OpenAIRE |
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