Longitudinal analysis of antibody responses in symptomatic malaria cases do not mirror parasite transmission in peri-urban area of Cote d’Ivoire between 2010 and 2013
| Autor: | Koffi, David, Varela, Marie-Louise, Loucoubar, Cheikh, Beourou, Sylvain, Vigan-Womas, Inès, Touré, Aissatou, Djaman, Joseph Allico, Touré, André Offianan, Perraut, Ronald, Snounou, Georges |
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| Přispěvatelé: | Institut Pasteur de Côte d’Ivoire, Abidjan, Côte d’Ivoire, Unité de Paludologie, Departament Fisica Aplicada i Optica, barcelona, Universitat de Barcelona (UB), Institut Pasteur de Dakar, Institut Pasteur de Dakar - Réseau International des Instituts Pasteur (RIIP), Institut Pasteur de Madagascar, Institut Pasteur de Madagascar - Réseau International des Instituts Pasteur (RIIP), Institut Cochin (UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS), Université Félix Houphouet Boigny, Abidjan, Côte d’Ivoire, UFR Biosciences, Muséum National d'Histoire Naturelle (MNHN), Institut Pasteur de Côte d'Ivoire, Réseau International des Instituts Pasteur (RIIP), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Muséum national d'Histoire naturelle (MNHN), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Félix Houphouët-Boigny (UFHB) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Plasmodium [SDV.BA] Life Sciences [q-bio]/Animal biology Quantitative Parasitology Physiology [SDV]Life Sciences [q-bio] Anopheles gambiae Antibody Response lcsh:Medicine Parasitemia Biochemistry Serology 0302 clinical medicine Immune Physiology Medicine and Health Sciences Malaria Falciparum Enzyme-Linked Immunoassays Child lcsh:Science antibody responses Immune Response MESH : Longitudinal analysis antibody responses symptomatic malaria parasite transmission peri-urban area Cote d'Ivoire Protozoans Immune System Proteins Multidisciplinary biology [SDV.BA]Life Sciences [q-bio]/Animal biology parasite transmission Malarial Parasites Longitudinal analysis 3. Good health [SDV] Life Sciences [q-bio] symptomatic malaria Child Preschool Female Antibody Research Article peri-urban area Plasmodium falciparum Immunology 030231 tropical medicine Enzyme-Linked Immunosorbent Assay Research and Analysis Methods Antibodies Herd immunity 03 medical and health sciences MESH: Longitudinal analysis antibody responses symptomatic malaria parasite transmission peri-urban area Cote d'Ivoire Immunity Anopheles Parasite Groups parasitic diseases Parasitic Diseases medicine Animals Humans Immunoassays Retrospective Studies lcsh:R Organisms Biology and Life Sciences Proteins Tropical Diseases biology.organism_classification medicine.disease Parasitic Protozoans Malaria Cross-Sectional Studies 030104 developmental biology Cote d'Ivoire Immunoglobulin G Antibody Formation Immunologic Techniques biology.protein Parasitology lcsh:Q Apicomplexa |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2017, 12 (2), pp.1-17. 〈10.1371/journal.pone.0172899〉 PLoS ONE, Vol 12, Iss 2, p e0172899 (2017) PLoS ONE, Public Library of Science, 2017, 12 (2), pp.1-17. ⟨10.1371/journal.pone.0172899⟩ |
| ISSN: | 1932-6203 |
| Popis: | Background In the agenda towards malaria eradication, assessment of both malaria exposure and efficacy of anti-vectorial and therapeutic strategies is a key component of management and the follow-up of field interventions. The simultaneous use of several antigens (Ags) as serological markers has the potential for accurate evaluation of malaria exposure. Here we aimed to measure the longitudinal evolution of the background levels of immunity in an urban setting in confirmed clinical cases of malaria. Methods A retrospective serological cross-sectional study on was carried out using 234 samples taken from 2010 to 2013 in peri-urban sentinel facility of Cote d’Ivoire. Antibody responses to recombinant proteins or BSA-peptides, 8 Plasmodium falciparum (PfAMA1, PfMSP4, PfMSP1, PfEMP1-DBL1α1-PF13, PfLSA1-41, PfLSA3-NR2, PfGLURP and PfCSP), one P. malariae (PmCSP) and one Anopheles gambiae salivary (gSG6-P1) antigens were measured using magnetic bead-based multiplex immunoassay (MBA). Total anti- P. falciparum IgG responses against schizont lysate from african 07/03 strain (adapted to culture) and 3D7 strain was measured by ELISA. Results High prevalence (7–93%) and levels of antibody responses to most of the antigens were evidenced. However, analysis showed only marginal decreasing trend of Ab responses from 2010 to 2013 that did not parallel the reduction of clinical malaria prevalence following the implementation of intervention in this area. There was a significant inverse correlation between Ab responses and parasitaemia (P |
| Databáze: | OpenAIRE |
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