Activation of macrophage mediated host defense against Salmonella typhimurium by Morus alba L
| Autor: | Bong-Seong Koo, Joa Sub Oh, Sung-Yeon Kim, BoYoon Chang, Hyeon-Cheol Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Salmonella lcsh:TX341-641 macrophage Biology Morus alba L medicine.disease_cause Microbiology 03 medical and health sciences 0302 clinical medicine Immune system medicine Secretion TLR4 Nutrition and Dietetics Innate immune system Lethal dose Public Health Environmental and Occupational Health immune defense biology.organism_classification 030104 developmental biology 030220 oncology & carcinogenesis Original Article Tumor necrosis factor alpha lcsh:Nutrition. Foods and food supply Bacteria Food Science |
| Zdroj: | Food & Nutrition Research, Vol 62, Iss 0, Pp 1-10 (2018) Food & Nutrition Research |
| Popis: | Background: The innate immune system plays a crucial role in the initiation and subsequent direction of adaptive immune responses, as well as in the removal of pathogens that have been targeted by an adaptive immune response. Objective: Morus alba L. was reported to have immunostimulatory properties that might protect against infectious diseases. However, this possibility has not yet been explored. The present study investigated the protective and immune-enhancing ability of M. alba L. against infectious disease and the mechanisms involved. Design: To investigate the immune-enhancing effects of M. alba L., we used a bacterial infection model. Results and discussions: The lifespan of mice infected with a lethal dose of Salmonella typhimurium (1 × 107 colony forming units – CFU) was significantly extended when they were administered M. alba L. Furthermore, M. alba L. activated macrophages, monocytes, and neutrophils and induced Th1 cytokines (IL-12, IFN-γ, TNF-α) in mice infected with a sublethal dose (1 × 105 CFU) of S. typhimurium. M. alba L. significantly stimulated the uptake of bacteria into peritoneal macrophages as indicated by increased phagocytosis. Peritoneal macrophages derived from C3H/HeJ mice significantly inhibited M. alba L. induced NO production and TNF-α secretion compared with peritoneal macrophages derived from C3H/HeN mice. Conclusions: These results suggest that the innate immune activity of M. alba L. against bacterial infection in mice occurs through activation of the TLR4 signaling pathway. |
| Databáze: | OpenAIRE |
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