Activity levels of some oxidoreductases of carbohydrate metabolism in leukoplakic and normal human buccal epithelium
| Autor: | Stanley Gerson, Sol Silverman |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Adult
Male Cancer Research Pentose Dehydrogenase Glucosephosphate Dehydrogenase Biology Pentose phosphate pathway Carbohydrate metabolism Buccal mucosa Pathology and Forensic Medicine medicine Humans Microdissection Aged chemistry.chemical_classification Mouth Mucosa Glyceraldehyde-3-Phosphate Dehydrogenases Microtomy Buccal administration Middle Aged Isocitrate Dehydrogenase Epithelium medicine.anatomical_structure Otorhinolaryngology Biochemistry chemistry Periodontics Female Mouth Neoplasms Leukoplakia Oral Oral Surgery |
| Zdroj: | Journal of Oral Pathology and Medicine. 2:77-85 |
| ISSN: | 1600-0714 0904-2512 |
| Popis: | The levels of activity of three oxidoreductases (glyceraldehyde-3-phosphate, NAD-de-pendent isocitrate, and glueose-6-phosphate dehydrogenases) were determined in pathologically keratinized (leukoplakic) and adjacent normal nonkeratinzed epithelium from the buccal mucosa of humans. Samples of histologically identifiable epithelial layers as well as of whole epithelium were isolated by microdissection from frozen-dried sections and assayed by ultramicrochemical methods. In the leukoplakic epithelium, as compared to the normal, glyceraldehyde-3-phosphate dehydrogenase activity was slightly higher, NAD-dependent isocitrate dehydrogenase activity was more than twice as high, and glucose-6-phosphate dehydrogenase activity was about l/3 lower. These findings suggest a higher potential for the formation of energy-rich compounds but a lower potential for pentose phosphogluconate pathway activity in the leukoplakic epithelium. |
| Databáze: | OpenAIRE |
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