Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression
| Autor: | Vishvanath Tiwari |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
AML1-ETO
myeloid leukemia-associated fusion protein Plant Components Protein Conformation Phytochemicals ENR enoyl acyl carrier reductase PyrD dihydroorotate dehydrogenase FabI NADH-dependent enoyl-ACP reductase Pharmaceutical Science mTOR mammalian target of rapamycin Computational biology Biology Cellular level Article Bax Bcl-2-associatedX Anti-neurodegenerative compound 03 medical and health sciences 0302 clinical medicine Protein structure Molecular level EGCG epigallocatechingallate HSP heat shock proteins Drug Discovery Animals Humans Native protein Anti-bacterial compound PARP poly ADP-ribose polymerase 030304 developmental biology Pharmacology chemistry.chemical_classification 0303 health sciences Plants Medicinal Future medicine Stability of proteins GTF glycosyltrasferases H-NS Histone-like nucleoid structuring protein DHA dihydroartemisinin Herbal active compounds Enzyme Complementary and alternative medicine chemistry HSF1 heat shock transcription factor 1 030220 oncology & carcinogenesis JNK c-Jun N-terminal kinase Molecular mechanism VDR vitamin D receptor Molecular Medicine Functional activity MAPK mitogen-activated protein kinase MMP-2 matrix metallo-proteinase-2 Phytotherapy |
| Zdroj: | Phytomedicine |
| ISSN: | 0944-7113 |
| DOI: | 10.1016/j.phymed.2018.09.214 |
| Popis: | Background Native protein conformation is essential for the functional activity of the proteins and enzymes. Defects in conformation or alterations in expression of the proteins have been reported in various diseases. Purpose The aim of this study is to review the molecular insight into the therapeutic potential of phytoconstituents targeting protein conformations or expressions. Methods Published literatures were searched in PubMed, Scopus, Web of Science; Article published till Dec 2017 were extracted. The literature was assessed from the Central University of Rajasthan, India. Present study evaluate article based on the role of active plant constituents on the conformation and expression of the different proteins. Results Plant components play their role either at the molecular level or cellular level and exhibit antibacterial, antiviral, anti-neurodegenerative and other activities. Plant active compounds isolated from different plants may either stabilize or destabilize the conformation of proteins or alter expression level of the protein involved in these diseases, therefore, can play a significant role in preventing diseases caused by the alteration in these proteins. Conclusion In the present article, we have reviewed the molecular mechanism of plant active compounds, their target proteins, methods of extraction and identification, and their biological significances. Therefore, a proper understanding of the effect of these herbal molecules on the concerned proteins may help to develop new herbal-based therapeutics for various diseases. |
| Databáze: | OpenAIRE |
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