An Intravenous 100-mL Lipid Emulsion Infusion Dramatically Improves Myocardial Glucose Metabolism Extinction in Cardiac FDG PET Clinical Practice
| Autor: | Valérie Nataf, Matthieu Dietz, Filippo Civaia, Benjamin Serrano, François Mocquot, Marc Faraggi, Florent Hugonnet, Frédéric Berthier, Benoit Paulmier |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Fat Emulsions Intravenous medicine.medical_specialty Carbohydrate metabolism Intracardiac injection 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Interquartile range Positron Emission Tomography Computed Tomography Internal medicine medicine Humans Endocarditis Radiology Nuclear Medicine and imaging In patient business.industry Myocardium Fdg uptake Biological Transport Heart General Medicine Middle Aged medicine.disease Clinical Practice Glucose 030220 oncology & carcinogenesis Cardiology Lipid emulsion Female business |
| Zdroj: | Clinical Nuclear Medicine. 46:e317-e324 |
| ISSN: | 1536-0229 0363-9762 |
| DOI: | 10.1097/rlu.0000000000003556 |
| Popis: | PURPOSE Physiological myocardial accumulation of FDG impairs the diagnosis of inflammatory/infectious or tumoral myocardial detection by FDG PET/CT. We prospectively evaluated the addition, 3 hours before imaging, of an intravenous 100-mL lipid emulsion infusion (Intralipid) to a high-fat, low-carbohydrate diet (HFLCD) for at least 2 meals followed by a fast of at least 6 to 12 hours in patients referred for the diagnosis of myocardial inflammation, endocarditis, cardiac or paracardiac masses, intracardiac device, or prosthetic valve infections. METHODS Data of 58 patients consecutively included (28 Intralipid patients, 30 controls with HFLCD alone) were compared. FDG uptake in normal myocardium was scored from 0 (complete myocardial suppression) to 3 (high diffuse uptake). Myocardial maximal, peak, and mean SUV and the rate of interpretable images according to the clinical indication were measured. RESULTS Compared with controls, Intralipid infusion significantly improved the rate of score 0 (89% vs 63%, P = 0.021), of interpretable images according to the clinical indication (100% vs 72%, P = 0.0047) and decreased all myocardial SUV values (eg, SUVmax median, 1.9 [interquartile range, 1.7-2.5] vs 3.1 [interquartile range, 2.3-4.1]; P < 0.001). CONCLUSIONS A lipid emulsion infusion in addition to HFLCD better suppresses cardiac glucose metabolism than HFLCD alone. |
| Databáze: | OpenAIRE |
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