Metabolic Factors Associated with Risk of Renal Cell Carcinoma
| Autor: | Göran Hallmans, Hans Concin, Randi Selmer, Hanno Ulmer, Pär Stattin, Jonas Manjer, Christel Häggström, Börje Ljungberg, Håkan Jonsson, Kilian Rapp, Steinar Tretli, Gabriele Nagel, Tone Bjørge, Anders Engeland, Tanja Stocks, Martin Almqvist |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Lifestyle Causes of Cancer Male Epidemiology urologic and male genital diseases Cardiovascular Cohort Studies chemistry.chemical_compound Renal cell carcinoma Risk Factors Urologi och njurmedicin Multidisciplinary Cancer Risk Factors female genital diseases and pregnancy complications Kidney Neoplasms Renal Cancer Hypertension Medicine Female Cancer Prevention Cancer Epidemiology Research Article Adult medicine.medical_specialty Clinical Research Design Science Urology Internal medicine medicine Humans Urology and Nephrology Obesity Statistical Methods Carcinoma Renal Cell Nutrition Proportional Hazards Models Proportional hazards model business.industry Cholesterol Renal Cell Carcinoma Cancers and Neoplasms medicine.disease Genitourinary Tract Tumors Endocrinology Increased risk Blood pressure chemistry Surgery business Body mass index |
| Zdroj: | PLoS ONE; 8(2), no e57475 (2013) PLoS ONE PLoS ONE, Vol 8, Iss 2, p e57475 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, and circulating levels of glucose, cholesterol, and triglycerides were collected from 560,388 men and women in cohorts from Norway, Austria, and Sweden. By use of Cox proportional hazard models, hazard ratios (HR) were calculated for separate and composite metabolic exposures. During a median follow-up of 10 years, 592 men and 263 women were diagnosed with RCC. Among men, we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 1.51, 95% CI 1.13-2.03), systolic blood pressure, (HR = 3.40, 95% CI 1.91-6.06), diastolic blood pressure, (HR = 3.33, 95% CI 1.85-5.99), glucose, (HR = 3.75, 95% CI 1.46-9.68), triglycerides, (HR = 1.79, 95% CI 1.00-3.21) and a composite score of these metabolic factors, (HR = 2.68, 95% CI 1.75-4.11). Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32-3.70) and the composite score, (HR = 2.29, 95% CI 1.12-4.68). High levels of the composite score were also associated with risk of death from RCC among both men and women. No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found. High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC. Finansiär: Lion’s Cancer Research Foundation, Umeå University, Sweden (LP 09-1799) |
| Databáze: | OpenAIRE |
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