Consumption of Ashtanga Ghrita (clarified cow butter added with herb extracts) improves cognitive dysfunction induced by scopolamine in rats via regulation of acetylcholinesterase activity and oxidative stress
| Autor: | Zeba Firdaus, Tryambak Deo Singh, Himanshu Rai, Dev Nath Singh Gautam, Prasanta Kumar Nayak, Vineet Sharma |
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| Rok vydání: | 2021 |
| Předmět: |
food.ingredient
Antioxidant medicine.medical_treatment Scopolamine Pharmacology medicine.disease_cause Terpene 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food medicine Animals Humans Pharmacology (medical) Cognitive Dysfunction General Pharmacology Toxicology and Pharmaceutics 030304 developmental biology chemistry.chemical_classification 0303 health sciences Plant Extracts Glycoside Neurodegenerative Diseases Acetylcholinesterase Amino acid Rats Oxidative Stress chemistry Phytochemical Herb Butter Cattle Female 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Drug metabolism and personalized therapyReferences. 36(4) |
| ISSN: | 2363-8915 2021-0108 |
| Popis: | Objectives Ashtanga Ghrita (AG), an Indian traditional formulation, has been used to promote neuropharmacological activities. AG is made up of clarified cow butter (ghee) and eight different herbs. Methods To test whether scopolamine (SCP)-induced dementia and brain oxidative stress can be counteracted by AG, rats were separated into five groups (n=6/group): group one control, group two SCP (1 mg/kg b.w., i.p.) treated and group three to five were co-treated with different doses of AG (1.25, 2.5 and 5 g/kg b.w., orally) and SCP. After the treatment regimen, behavioral (Y-maze test) and brain biochemical changes were measured in all groups. Results Microbial load and heavy metals were found within permissible limits. Results from attenuated total reflection Fourier-transform infrared spectroscopy demonstrated the complexation/interaction of herbal phytoconstituents with the functional groups of Ghrita. Preliminary phytochemical analysis of AG exhibited the occurrence of flavonoids, phenolics, glycosides, steroids, triterpenes, tannins, and amino acids. Findings of the experimental study exhibited that AG significantly protected the rats from SCP-induced behavioral dysfunction and brain biochemical alterations. Conclusions This study demonstrates that AG protects the brain from SCP-induced dementia by promoting brain antioxidant activity and thus could be a promising drug for the treatment of neurodegenerative disease. |
| Databáze: | OpenAIRE |
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