Sex differences in soluble prorenin receptor in patients with type 2 diabetes
Autor: | Minolfa C. Prieto, Jennifer Hong, Mohammed A. Feroz, Tina K. Thethi, Andrew C. Curnow, Christina Luffman, Edgar A. Jaimes, Vivian Fonseca, Carla B. Rosales, Franck Mauvais-Jarvis, Michael J. Accavitti, Gabrielle Dawkins, Bruna Visniauskas, Danielle Y Arita, John J. Lefante |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Physiology Receptors Cell Surface Stimulation Type 2 diabetes Urine 030204 cardiovascular system & hematology Plasma renin activity Preeclampsia Gender Studies Sexual dimorphism 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Renin eGFR medicine Humans QP1-981 Prorenin Receptor ATP6AP2 Sex Characteristics business.industry Research Middle Aged medicine.disease Urine renin activity Urine angiotensinogen 030104 developmental biology Diabetes Mellitus Type 2 Medicine Female Kidney Diseases business Body mass index Kidney disease |
Zdroj: | Biology of Sex Differences, Vol 12, Iss 1, Pp 1-12 (2021) Biology of Sex Differences |
ISSN: | 2042-6410 |
Popis: | Background The soluble prorenin receptor (sPRR), a member of the renin-angiotensin system (RAS), is elevated in plasma of patients with preeclampsia, hypertension, chronic kidney disease (CKD), and type 2 diabetes. Our goal was to examine the relationship between sPRR and RAS activation to define whether sexual dimorphisms in sPRR might explain sex disparities in renal outcomes in patients with type 2 diabetes. Methods Two hundred sixty-nine participants were included in the study (mean age, 48 ± 16 years; 42% men, 58% women), including 173 controls and 96 subjects with type 2 diabetes. In plasma and urine, we measured sPRR, plasma renin activity (PRA), and prorenin. In the urine, we also measured angiotensinogen along with other biomarkers of renal dysfunction. Results Plasma sPRR and PRA were significantly higher in women with type 2 diabetes compared to men. In these women, plasma sPRR was positively correlated with PRA, age, and body mass index (BMI). In contrast, in men the sPRR in urine but not in plasma positively correlated with eGFR in urine, but negatively correlated with urine renin activity, plasma glucose, age, and BMI. Conclusions In patients with type 2 diabetes, sPRR contributes to RAS stimulation in a sex-dependent fashion. In diabetic women, increased plasma sPRR parallels the activation of systemic RAS; while in diabetic men, decreased sPRR in urine matches intrarenal RAS stimulation. sPRR might be a potential indicator of intrarenal RAS activation and renal dysfunction in men and women with type 2 diabetes. |
Databáze: | OpenAIRE |
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