Efficacy of a silver colloidal gel against selected oral bacteria in vitro
| Autor: | Keaton Luth, James C. Wang, Ted W. Reid, Anselm de Souza, Coby Ray, Phat Tran, C. D. Moeller, K. W. Moeller, Dilip S. Mehta |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Silver dental plaque 030106 microbiology Dental plaque General Biochemistry Genetics and Molecular Biology biofilm Microbiology Streptococcus mutans 03 medical and health sciences 0302 clinical medicine SILVER COLLOIDAL stomatognathic system medicine General Pharmacology Toxicology and Pharmaceutics Colony-forming unit Mouth General Immunology and Microbiology biology Chemistry Microbiota Biofilm Colloidal silver 030206 dentistry General Medicine Articles biology.organism_classification medicine.disease In vitro stomatognathic diseases Streptococcus salivarius Biofilms dental caries Bacteria Research Article |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| Popis: | Background:It is necessary to develop new strategies to protect against bacteria such as Streptococcus mutans, Streptococcus sanguis, andStreptococcus salivarius, which contribute to tooth decay and plaque formation. Our current study investigated the efficacy of a colloidal silver gel in inhibiting biofilm formation by these principal oral bacteria, in vitro. The aim of this study was to assess the efficacy of a colloidal silver gel formulation for inhibiting bacterial biofilm formation (Ag-gel) by the principal bacteria that cause plaque formation and tooth decay.Methods:The effect of Ag-gel on viability ofS. mutans,S. sanguis,and S. salivariuswas assessed by quantifying their colony forming units (CFU) in presence or absence of the test gel. The effect of this formulation on biofilm-forming ability of these bacteria was studied through scanning electron microscopy.Results:Using the CFU assays, over 6 logs of inhibition (100%) were found forS. mutans,S. sanguis, andS. salivariusfor the Ag-gel-treated bacteria when compared with the control gel. In addition, the Ag-gel also inhibited biofilm formation by these three bacteria mixed together. These results were confirmed by scanning electron microscopy.Conclusions:The Ag-gel was effective in preventing biofilm formation byS. mutans, S. sanguis, and S. salivarius. This Ag-gel should be tested for the ability to block plaque formation in the mouth, through its use as a tooth paste. |
| Databáze: | OpenAIRE |
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