Insecticidal and Repellant Activities of Polyacetylenes and Lactones Derived from Atractylodes lancea Rhizomes
| Autor: | Ning Lei, Li-Shi Zheng, Qian Cai, Ping Ma, Zhu-Feng Geng, Hai-Ping Chen, Kai Yang, Shu-Shan Du, Zhi-Wei Deng |
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| Rok vydání: | 2015 |
| Předmět: |
Insecticides
Magnetic Resonance Spectroscopy animal structures Stereochemistry Drug Evaluation Preclinical Bioengineering Biochemistry Lactones Structure-Activity Relationship chemistry.chemical_compound Animals Atractylenolide II Petroleum ether Furans Molecular Biology Volume concentration Tribolium Dose-Response Relationship Drug biology Traditional medicine Chemistry fungi Polyynes Atractylodes General Chemistry General Medicine biology.organism_classification Rhizome Chromatographic separation Insect Repellents Molecular Medicine Atractylodin Medicinal herbs Atractylodes lancea Sesquiterpenes |
| Zdroj: | Chemistry & Biodiversity. 12:593-598 |
| ISSN: | 1612-1880 1612-1872 |
| Popis: | During a screening program for new agrochemicals from Chinese medicinal herbs and local wild plants, the petroleum ether (PE) extract of Atractylodes lancea (Thunb.) rhizomes was found to possess repellent and contact activities against Tribolium castaneum adults. Bioactivity-directed chromatographic separation of PE extract on repeated silica-gel columns led to the isolation of two polyacetylenes, atractylodin and atractylodinol (1 and 2, resp.), and two lactones, atractylenolides II and III (3 and 4, resp.). The structures of the compounds were elucidated based on NMR spectra. The four isolated compounds were evaluated for their insecticidal and repellent activities against T. castaneum. Atractylodin exhibited strong contact activity against T. castaneum adults with a LD50 value of 1.83 μg/adult. Atractylodin and atractylenolide II also possessed strong repellenct activities against T. castaneum adults. After 4-h exposure,90% repellency was achieved with atractylodin at a low concentration of 0.63 μg/cm(2) . The results indicated that atractylodin (1) and atractylenolide II (3) have a good potential as a source for natural repellents, and 1 has the potential to be developed as natural insecticide. |
| Databáze: | OpenAIRE |
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