Mutational analysis of hematologic neoplasms in 164 paired peripheral blood and bone marrow samples by next-generation sequencing
| Autor: | Phillip Michaels, Dahai Wang, Annette S. Kim, Fabienne Lucas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty DNA Mutational Analysis Hematologic Neoplasms Disease DNA sequencing 03 medical and health sciences 0302 clinical medicine Bone Marrow hemic and lymphatic diseases Retrospective analysis Medicine Humans Single institution business.industry High-Throughput Nucleotide Sequencing Hematology Stimulus Report Peripheral blood Mutational analysis medicine.anatomical_structure 030220 oncology & carcinogenesis Bone marrow business 030215 immunology |
| Zdroj: | Blood Adv |
| Popis: | The classification, risk stratification, and treatment selection of patients with hematologic malignancies are heavily influenced by recurrent molecular alterations determined by next-generation sequencing (NGS).1-5 Peripheral blood (PB) and bone marrow (BM) are generally considered equivalent sample sources, especially if similarly involved by disease, but large studies comparing the mutational profiles of paired PB and BM samples (ie, taken from the same patient at the same time point of their disease history) have not been performed.6,7 We report a retrospective analysis of 164 patients from a single institution with suspected or known hematologic diseases for whom both PB and BM NGS was performed. |
| Databáze: | OpenAIRE |
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