Light-induced retinal damage using different light sources, protocols and rat strains reveals LED phototoxicity

Autor: Emilie Picard, R. Levy-Boukris, Alicia Torriglia, A. Krigel, Laurent Jonet, M. Dernigoghossian, Charlotte Andrieu-Soler, Imene Jaadane, Francine Behar-Cohen, Marianne Berdugo
Přispěvatelé: HAL-UPMC, Gestionnaire, Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers ( CRC ), Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
medicine.medical_specialty
Light
Photoperiod
Fluorescent Antibody Technique
Skin Pigmentation
Biology
Retina
law.invention
Phototoxicity
03 medical and health sciences
0302 clinical medicine
law
Ophthalmology
Electroretinography
In Situ Nick-End Labeling
medicine
Animals
Drosophila Proteins
Pigmented rats
Rats
Long-Evans
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Rats
Wistar
Lighting
Incandescent light bulb
Chronic light exposure
medicine.diagnostic_test
General Neuroscience
Aryl Hydrocarbon Receptor Nuclear Translocator
Retinal Degeneration
Illuminance
Dose-Response Relationship
Radiation
Equipment Design
Macular degeneration
medicine.disease
Light emitting diodes
3. Good health
Dose–response relationship
030104 developmental biology
medicine.anatomical_structure
[ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
030221 ophthalmology & optometry
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Photic Stimulation
Light-emitting diode
Zdroj: Neuroscience
Neuroscience, Elsevier-International Brain Research Organization, 2016, ⟨10.1016/j.neuroscience.2016.10.015⟩
Neuroscience, Elsevier-International Brain Research Organization, 2016, 〈10.1016/j.neuroscience.2016.10.015〉
Neuroscience, 2016, ⟨10.1016/j.neuroscience.2016.10.015⟩
ISSN: 0306-4522
1873-7544
DOI: 10.1016/j.neuroscience.2016.10.015
Popis: International audience; To save energy, the European directives from the Eco-design of Energy Using Products (2005/32/CE) has recommended the replacement of incandescent lamps by more economic devices such as Light Emitting Diodes (LEDs). However, the emission spectrum of these devices is enriched in blue radiations, known to be potentially dangerous to the retina. Recent studies showed that light exposure contribute to the onset of early stages of Age related macular degeneration (AMD). Here, we investigate, in albinos and pigmented rats, the effects of different exposure protocols. Twenty-four hours exposure at high luminance was compared to a cyclic (dark/light) exposure at domestic levels for 1 week and 1 month, using different LEDs (Cold-white, blue and green), as well as fluorocompacts bulbs and fluorescent tubes.The data suggest that the blue component of the white-LED may cause retinal toxicity at occupational domestic illuminance and not only in extreme experimental conditions, as previously reported. It is important to note that the current regulations and standards have been established on the basis of acute light exposure and do not take into account the effects of repeated exposure.
Databáze: OpenAIRE
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