Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima-media thickness
| Autor: | Daniel T. Lackland, M B McHenry, Dcct, Timothy J. Lyons, Deyi Zheng, W T Garvey, Maria F. Lopes-Virella, James D. Otvos, Daniel L. McGee, Alicia J. Jenkins, Yongxin Yu, Richard L. Klein |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Very low-density lipoprotein medicine.medical_specialty Magnetic Resonance Spectroscopy Apolipoprotein B Carotid Artery Common Lipoproteins Endocrinology Diabetes and Metabolism Diabetic angiopathy Endocrinology Nuclear magnetic resonance Diabetes mellitus Internal medicine Internal Medicine medicine Humans cardiovascular diseases Ultrasonography Intermediate-density lipoprotein biology business.industry Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 Intima-media thickness cardiovascular system biology.protein Body Constitution Female lipids (amino acids peptides and proteins) Tunica Intima Tunica Media business Carotid Artery Internal Diabetic Angiopathies Lipoprotein Chylomicron |
| Zdroj: | Diabetic Medicine. 23:955-966 |
| ISSN: | 1464-5491 0742-3071 |
| Popis: | Aims To relate nuclear magnetic resonance lipoprotein subclass profiles (NMR-LSP) and other lipoprotein-related factors with carotid intima-media thickness (IMT) in Type 1 diabetes. Methods Lipoprotein-related factors were determined in sera (obtained in 1997–1999) from 428 female [age 39 ± 7 years (mean ± sd)] and 540 male (age 40 ± 7 years) Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) participants. NMR quanti-fies chylomicrons, three very low-density lipoprotein (VLDL) subclasses, intermediate density lipoprotein (IDL), three low-density lipoprotein (LDL) subclasses, two high-density lipoprotein (HDL) subclasses, mean VLDL, LDL and HDL size, and LDL particle concentration. Conventional lipids, ApoA1, ApoB and Lp(a) and in vitro LDL oxidizibility were also measured. IMT was determined (in 1994–1995) using high-resolution B-mode ultrasound. Relationships between IMT and lipoproteins were analysed by multiple linear regression, controlling for age, diabetes-related factors, and cardiovascular disease (CVD) risk factors. Results IMT associations with lipoproteins were stronger for the internal than the common carotid artery, predominantly involving LDL. Internal carotid IMT was positively (P |
| Databáze: | OpenAIRE |
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