An imaging-based approach to the evaluation of xerostomia
| Autor: | Paloma Pimenta, Joseph Youssef, Alden Calantog, Steven Duong, Jun Zhang, Holly Aguigam, Petra Wilder-Smith, Masters James G, Shira Pilch |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male business.product_category Dentistry Dermatology Placebo Xerostomia Article Optical coherence tomography stomatognathic system Tongue Fluoride toothpaste Medicine Humans In patient Toothpaste Cross-Over Studies medicine.diagnostic_test business.industry Middle Aged Dry mouth Crossover study medicine.anatomical_structure Surgery Female sense organs medicine.symptom business Tomography Optical Coherence Toothpastes |
| Zdroj: | Duong, S; Youssef, J; Pimenta, P; Aguigam, H; Zhang, J; Calantog, A; et al.(2012). An imaging-based approach to the evaluation of xerostomia.. Lasers in surgery and medicine, 44(6), 482-489. doi: 10.1002/lsm.22039. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2658j9rz |
| ISSN: | 1096-9101 |
| DOI: | 10.1002/lsm.22039. |
| Popis: | Author(s): Duong, Steven; Youssef, Joseph; Pimenta, Paloma; Aguigam, Holly; Zhang, Jun; Calantog, Alden; Pilch, Shira; Masters, James G; Wilder-Smith, Petra | Abstract: Background and objectiveGoal was to evaluate the potential of in vivo optical coherence tomography (OCT) imaging to determine the response of patients with xerostomia to a dry mouth toothpaste versus fluoride toothpaste placebo.Study design/materials and methodsTen subjects with xerostomia participated in this double-blind, crossover, placebo-controlled study. After examination and OCT imaging, subjects used the first product for 15 days, followed by a 7-day washout period, and then they used the second product for 15 days. Data were acquired at 5-day intervals, also before and after the washout.ResultsVisual examination and tongue blade adhesion test did not reflect response to the product. Two imaging-based markers were identified: (i) In OCT images, epithelial thickness increased significantly (P l 0.05) after use of the dry mouth toothpaste, but did not change significantly (P g 0.05) after the use of a fluoride toothpaste and (2) Optical backscattering data showed progressive characteristic changes from baseline with use of the active product.ConclusionsIn this pilot study using in vivo OCT imaging, it was possible to detect and measure oral epithelial response to the dry mouth product versus placebo in patients with xerostomia.Clinical implicationsThis approach may permit site-specific assessment of xerostomia, individualized treatment planning and monitoring, and sequential mucosal mapping in patients with dry mouth. |
| Databáze: | OpenAIRE |
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