STATUS OF THE SYSTEM OF SIGNALING PATTERN RECOGNITION RECEPTORS OF MONOCYTES AND GRANULOCYTES IN COSMONAUTS' PERIPHERAL BLOOD BEFORE AND AFTER LONG-DURATION MISSIONS TO THE INTERNATIONAL SPACE STATION
| Autor: | T. A. Berendeeva, S.A. Kalinin, A. V. Muranova, S. A. Ponomarev |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male chemical and pharmacologic phenomena Endogeny Biology General Biochemistry Genetics and Molecular Biology Monocytes 03 medical and health sciences Humans Receptor Pattern recognition receptor TLR9 General Medicine Middle Aged Space Flight Toll-Like Receptor 2 Toll-Like Receptor 4 TLR2 030104 developmental biology Immunology TLR3 TLR4 Aerospace Medicine Astronauts HSP60 Granulocytes Signal Transduction |
| Zdroj: | Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine. 50(5) |
| ISSN: | 0233-528X |
| Popis: | The system of signaling pattern recognition receptors was studied in 8 cosmonauts aged 35 to 56 years before and after (R+) long-duration missions to the International space station. Peripheral blood samples were analyzed for the content of monocytes and granulocytes that express the signaling pattern recognition Toll- like (TLR) receptors localized as on cell surface (TLR1, TLR2, TLR4, TLR5, TLR6), so inside cells (TLR3, TLR8, TLR9). In parallel, serum concentrations of TLR2 (HSP60) and TLR4 ligands (HSP70, HMGB1) were measured. The results of investigations showed growth of HSP60, HSP70 and HMGB1 concentrations on R+1. In the;majority of cosmonauts increases in endogenous ligands were followed by growth in the number of both monocytes and granulocytes that express TLR2 1 TLR4. This consistency gives ground to assume that changes in the system of signaling pattern recognition receptors can stem .from the predominantly endogenous ligands' response to the effects of long-duration space flight on human organism. |
| Databáze: | OpenAIRE |
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