Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites

Autor: Badara Cisse, Cheikh Sokhna, Sylvie Cornelie, Cheikh Sow, François Simondon, Denis Boulanger, Marie-Noëlle Rossignol, Franck Remoue, Anne Poinsignon, Fatou Ba
Přispěvatelé: Caractérisation et contrôle des populations de vecteurs, Institut de Recherche pour le Développement (IRD), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD [France-Sud]), Épidémiologie et prévention : environnement et efficacité des interventions (EPIPREV), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Male
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
Anopheles gambiae
030231 tropical medicine
Context (language use)
Insect bites and stings
lcsh:Infectious and parasitic diseases
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Anopheles
parasitic diseases
medicine
Animals
Humans
lcsh:RC109-216
Salivary Proteins and Peptides
030304 developmental biology
0303 health sciences
biology
Research
Infant
Insect Bites and Stings
medicine.disease
biology.organism_classification
Senegal
3. Good health
Biomarker
Infectious Diseases
Parasitology
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology
Vector (epidemiology)
Child
Preschool
Immunoglobulin G
Immunology
Insect Proteins
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Malaria
Biomarkers
Zdroj: Malaria Journal
Malaria Journal, BioMed Central, 2009, 8, pp.198. ⟨10.1186/1475-2875-8-198⟩
Malaria Journal, 2009, 8, pp.198. ⟨10.1186/1475-2875-8-198⟩
Malaria Journal, Vol 8, Iss 1, p 198 (2009)
ISSN: 1475-2875
DOI: 10.1186/1475-2875-8-198⟩
Popis: Background Human populations exposed to low malaria transmission present particular severe risks of malaria morbidity and mortality. In addition, in a context of low-level exposure to Anopheles vector, conventional entomological methods used for sampling Anopheles populations are insufficiently sensitive and probably under-estimate the real risk of malaria transmission. The evaluation of antibody (Ab) responses to arthropod salivary proteins constitutes a novel tool for estimating exposure level to insect bites. In the case of malaria, a recent study has shown that human IgG responses to the gSG6-P1 peptide represented a specific biomarker of exposure to Anopheles gambiae bites. The objective of this study was to investigate if this biomarker can be used to estimate low-level exposure of individuals to Anopheles vector. Methods The IgG Ab level to gSG6-P1 was evaluated at the peak and at the end of the An. gambiae exposure season in children living in Senegalese villages, where the Anopheles density was estimated to be very low by classical entomological trapping but where malaria transmission occurred during the studied season. Results Specific IgG responses to gSG6-P1 were observed in children exposed to very low-level of Anopheles bites. In addition, a significant increase in the specific IgG Ab level was observed during the Anopheles exposure season whereas classical entomological data have reported very few or no Anopheles during the studied period. Furthermore, this biomarker may also be applicable to evaluate the heterogeneity of individual exposure. Conclusion The results strengthen the hypothesis that the evaluation of IgG responses to gSG6-P1 during the season of exposure could reflect the real human contact with anthropophilic Anopheles and suggest that this biomarker of low exposure could be used at the individual level. This promising immuno-epidemiological marker could represent a useful tool to assess the risk to very low exposure to malaria vectors as observed in seasonal, urban, altitude or travellers contexts. In addition, this biomarker could be used for the surveillance survey after applying anti-vector strategy.
Databáze: OpenAIRE
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